tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2022 Aug 17;9(9)
fac425.
doi: 10.1093/ofid/ofac425. eCollection 2022 Sep.
Post-Lung Transplantation Outcomes and Ex Vivo Histopathological Findings in Severe Post-Covid-19 Pulmonary Disease-A Single-Center Experience
Hana Javaid[SUP] 1 [/SUP], Masayuki Nigo[SUP] 1 [/SUP], Bihong Zhao[SUP] 2 [/SUP], Daniel Ocazionez Trujillo[SUP] 3 [/SUP], Rodrigo Hasbun[SUP] 1 [/SUP], Luis Ostrosky-Zeichner[SUP] 1 [/SUP], Manish Patel[SUP] 4 [/SUP], Soma Jyothula[SUP] 5 [/SUP]
Affiliations
Abstract
Background: A significant proportion of patients with severe and persistent coronavirus disease 2019 (COVID-19) require continuous ventilatory support and occasional extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS). Lung transplantation is a treatment option for patients who develop severe ARDS.
Methods: Our lung transplant database was retrospectively reviewed for patients who underwent lung transplantation for COVID-19 pulmonary disease at Memorial Hermann Hospital, Texas Medical Center, Houston, Texas, from January 2020 to March 2022. We evaluated outcomes of patients who were followed in our clinic at least 6 months post-transplant. Pretransplant patient characteristics, COVID-19-related treatment, histopathology results, and postdischarge course were evaluated.
Results: Among a total of 13 lung transplant recipients, 6 consecutive patients were identified who had a minimum of 6 months of follow-up post-lung transplantation. The average age of patients was 55 years, with a male predominance. The median time to transplantation was 111 days. All 6 patients had significant postinfectious complications due to COVID-19 before transplant. Histopathological findings from explanted lungs showed a predominance of fibrotic change. There were no reported cases of rejection or graft dysfunction. 5 patients had minimal to no post-transplant infectious complications. One patient died 218 days post-transplant from infectious complications.
Conclusions: Five out of six lung transplant recipients at our institution have demonstrated excellent long-term outcomes after index hospitalization, for a mean follow-up of 13 months post-lung transplantation. Lung transplantation for lung fibrosis due to COVID-19 is an acceptable salvage treatment option. Larger studies are warranted to confirm these findings.
Keywords: ARDS; COVID-19; hospitalization; lung transplantation; outcomes.
. 2022 Aug 17;9(9)
fac425.doi: 10.1093/ofid/ofac425. eCollection 2022 Sep.
Post-Lung Transplantation Outcomes and Ex Vivo Histopathological Findings in Severe Post-Covid-19 Pulmonary Disease-A Single-Center Experience
Hana Javaid[SUP] 1 [/SUP], Masayuki Nigo[SUP] 1 [/SUP], Bihong Zhao[SUP] 2 [/SUP], Daniel Ocazionez Trujillo[SUP] 3 [/SUP], Rodrigo Hasbun[SUP] 1 [/SUP], Luis Ostrosky-Zeichner[SUP] 1 [/SUP], Manish Patel[SUP] 4 [/SUP], Soma Jyothula[SUP] 5 [/SUP]
Affiliations
- PMID: 36072698
- PMCID: PMC9439573
- DOI: 10.1093/ofid/ofac425
Abstract
Background: A significant proportion of patients with severe and persistent coronavirus disease 2019 (COVID-19) require continuous ventilatory support and occasional extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS). Lung transplantation is a treatment option for patients who develop severe ARDS.
Methods: Our lung transplant database was retrospectively reviewed for patients who underwent lung transplantation for COVID-19 pulmonary disease at Memorial Hermann Hospital, Texas Medical Center, Houston, Texas, from January 2020 to March 2022. We evaluated outcomes of patients who were followed in our clinic at least 6 months post-transplant. Pretransplant patient characteristics, COVID-19-related treatment, histopathology results, and postdischarge course were evaluated.
Results: Among a total of 13 lung transplant recipients, 6 consecutive patients were identified who had a minimum of 6 months of follow-up post-lung transplantation. The average age of patients was 55 years, with a male predominance. The median time to transplantation was 111 days. All 6 patients had significant postinfectious complications due to COVID-19 before transplant. Histopathological findings from explanted lungs showed a predominance of fibrotic change. There were no reported cases of rejection or graft dysfunction. 5 patients had minimal to no post-transplant infectious complications. One patient died 218 days post-transplant from infectious complications.
Conclusions: Five out of six lung transplant recipients at our institution have demonstrated excellent long-term outcomes after index hospitalization, for a mean follow-up of 13 months post-lung transplantation. Lung transplantation for lung fibrosis due to COVID-19 is an acceptable salvage treatment option. Larger studies are warranted to confirm these findings.
Keywords: ARDS; COVID-19; hospitalization; lung transplantation; outcomes.