tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2022 Mar 2;9(3)
fac055.
doi: 10.1093/ofid/ofac055. eCollection 2022 Mar.
Low Levels of Neutralizing Antibodies After Natural Infection With Severe Acute Respiratory Syndrome Coronavirus 2 in a Community-Based Serological Study
Thomas W McDade[SUP] 1 2 [/SUP], Amelia Sancilio[SUP] 1 2 [/SUP], Richard D'Aquila[SUP] 3 [/SUP], Brian Mustanski[SUP] 4 5 [/SUP], Lauren A Vaught[SUP] 6 7 [/SUP], Nina L Reiser[SUP] 6 7 [/SUP], Matthew E Velez[SUP] 6 7 [/SUP], Ryan R Hsieh[SUP] 6 7 [/SUP], Daniel T Ryan[SUP] 4 5 [/SUP], Rana Saber[SUP] 4 5 [/SUP], Elizabeth M McNally[SUP] 6 7 8 [/SUP], Alexis R Demonbreun[SUP] 6 9 [/SUP]
Affiliations
Abstract
Background: Confidence in natural immunity after infection with severe acute respiratory syndrome coronavirus 2 is one reason for vaccine hesitancy.
Methods: We measured antibody-mediated neutralization of spike protein-ACE2 receptor binding in a large community-based sample of seropositive individuals who differed in severity of infection (N = 790).
Results: A total of 39.8% of infections were asymptomatic, 46.5% were symptomatic with no clinical care, 13.8% were symptomatic with clinical care, and 3.7% required hospitalization. Moderate/high neutralizing activity was present after 41.3% of clinically managed infections, in comparison with 7.9% of symptomatic and 1.9% of asymptomatic infections.
Conclusions: Prior coronavirus disease 2019 infection does not guarantee a high level of antibody-mediated protection against reinfection in the general population.
Keywords: COVID-19; SARS-CoV-2; neutralizing antibodies; serological testing; vaccination.
. 2022 Mar 2;9(3)
fac055.doi: 10.1093/ofid/ofac055. eCollection 2022 Mar.
Low Levels of Neutralizing Antibodies After Natural Infection With Severe Acute Respiratory Syndrome Coronavirus 2 in a Community-Based Serological Study
Thomas W McDade[SUP] 1 2 [/SUP], Amelia Sancilio[SUP] 1 2 [/SUP], Richard D'Aquila[SUP] 3 [/SUP], Brian Mustanski[SUP] 4 5 [/SUP], Lauren A Vaught[SUP] 6 7 [/SUP], Nina L Reiser[SUP] 6 7 [/SUP], Matthew E Velez[SUP] 6 7 [/SUP], Ryan R Hsieh[SUP] 6 7 [/SUP], Daniel T Ryan[SUP] 4 5 [/SUP], Rana Saber[SUP] 4 5 [/SUP], Elizabeth M McNally[SUP] 6 7 8 [/SUP], Alexis R Demonbreun[SUP] 6 9 [/SUP]
Affiliations
- PMID: 35252468
- PMCID: PMC8890497
- DOI: 10.1093/ofid/ofac055
Abstract
Background: Confidence in natural immunity after infection with severe acute respiratory syndrome coronavirus 2 is one reason for vaccine hesitancy.
Methods: We measured antibody-mediated neutralization of spike protein-ACE2 receptor binding in a large community-based sample of seropositive individuals who differed in severity of infection (N = 790).
Results: A total of 39.8% of infections were asymptomatic, 46.5% were symptomatic with no clinical care, 13.8% were symptomatic with clinical care, and 3.7% required hospitalization. Moderate/high neutralizing activity was present after 41.3% of clinically managed infections, in comparison with 7.9% of symptomatic and 1.9% of asymptomatic infections.
Conclusions: Prior coronavirus disease 2019 infection does not guarantee a high level of antibody-mediated protection against reinfection in the general population.
Keywords: COVID-19; SARS-CoV-2; neutralizing antibodies; serological testing; vaccination.