tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 Mar 28;10(4)
fad167.
doi: 10.1093/ofid/ofad167. eCollection 2023 Apr.
Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination
Xuemin Chen[SUP] 1 2 [/SUP], Caroline Ciric[SUP] 1 [/SUP], Theda Gibson[SUP] 1 [/SUP], Larry J Anderson[SUP] 1 2 [/SUP], Evan J Anderson[SUP] 1 2 3 [/SUP], Christina A Rostad[SUP] 1 2 [/SUP]
Affiliations
Abstract
In this longitudinal prospective cohort of healthy adults in the United States, we found that coronavirus disease 2019 messenger RNA primary series and booster vaccinations elicited high titers of broadly cross-reactive neutralizing and antibody-dependent cell-mediated cytotoxicity antibodies, which gradually waned over 6 months, particularly against severe acute respiratory syndrome coronavirus 2 variants. These data support the indication for a subsequent booster vaccination.
Keywords: ADCC; Omicron; antibody-dependent cell-mediated cytotoxicity; durability; hybrid immunity.
. 2023 Mar 28;10(4)
fad167.doi: 10.1093/ofid/ofad167. eCollection 2023 Apr.
Longitudinal Neutralizing and Functional Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 Variants Following Messenger RNA Coronavirus Disease 2019 Vaccination
Xuemin Chen[SUP] 1 2 [/SUP], Caroline Ciric[SUP] 1 [/SUP], Theda Gibson[SUP] 1 [/SUP], Larry J Anderson[SUP] 1 2 [/SUP], Evan J Anderson[SUP] 1 2 3 [/SUP], Christina A Rostad[SUP] 1 2 [/SUP]
Affiliations
- PMID: 37065985
- PMCID: PMC10096895
- DOI: 10.1093/ofid/ofad167
Abstract
In this longitudinal prospective cohort of healthy adults in the United States, we found that coronavirus disease 2019 messenger RNA primary series and booster vaccinations elicited high titers of broadly cross-reactive neutralizing and antibody-dependent cell-mediated cytotoxicity antibodies, which gradually waned over 6 months, particularly against severe acute respiratory syndrome coronavirus 2 variants. These data support the indication for a subsequent booster vaccination.
Keywords: ADCC; Omicron; antibody-dependent cell-mediated cytotoxicity; durability; hybrid immunity.