tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 Jun 13;10(7)
fad315.
doi: 10.1093/ofid/ofad315. eCollection 2023 Jul. Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness
May ElSherif[SUP] 1 [/SUP], Melissa K Andrew[SUP] 1 [/SUP], Lingyun Ye[SUP] 1 [/SUP], Ardith Ambrose[SUP] 1 [/SUP], Guy Boivin[SUP] 2 [/SUP], William Bowie[SUP] 3 [/SUP], Marie-Pierre David[SUP] 4 [/SUP], Olivier Gruselle[SUP] 4 [/SUP], Scott A Halperin[SUP] 1 [/SUP], Todd F Hatchette[SUP] 1 [/SUP], Jennie Johnstone[SUP] 5 [/SUP], Kevin Katz[SUP] 6 [/SUP], Joanne M Langley[SUP] 1 [/SUP], Mark Loeb[SUP] 7 [/SUP], Donna MacKinnon-Cameron[SUP] 1 [/SUP], Anne McCarthy[SUP] 8 [/SUP], Janet E McElhaney[SUP] 9 [/SUP], Allison McGeer[SUP] 10 [/SUP], Andre Poirier[SUP] 11 [/SUP], Jean-Yves Pirçon[SUP] 4 [/SUP], Jeff Powis[SUP] 12 [/SUP], David Richardson[SUP] 13 [/SUP], Makeda Semret[SUP] 14 [/SUP], Stephanie Smith[SUP] 15 [/SUP], Daniel Smyth[SUP] 16 [/SUP], Sylvie Trottier[SUP] 2 [/SUP], Louis Valiquette[SUP] 17 [/SUP], Duncan Webster[SUP] 18 [/SUP], Shelly A McNeil[SUP] 1 [/SUP], Jason J LeBlanc[SUP] 1 [/SUP]; Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN) and the Toronto Invasive Bacterial Diseases Network (TIBDN)
Affiliations
Background: Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50 years hospitalized with RSV.
Methods: Using administrative data and nasopharyngeal swabs collected from active surveillance among adults aged ≥50 years hospitalized with an acute respiratory illness (ARI) during the 2012-2013, 2013-2014, and 2014-2015 influenza seasons, RSV was identified using a respiratory virus multiplex polymerase chain reaction test to describe the associated disease burden, incidence, and healthcare costs.
Results: Of 7797 patients tested, 371 (4.8%) were RSV positive (2.2% RSV-A and 2.6% RSV-B). RSV prevalence varied by season from 4.2% to 6.2%. Respiratory virus coinfection was observed in 11.6% (43/371) of RSV cases, with influenza A being the most common. RSV hospitalization rates varied between seasons and increased with age, from 8-12 per 100 000 population in adults aged 50-59 years to 174-487 per 100 000 in adults aged ≥80 years. The median age of RSV cases was 74.9 years, 63.7% were female, and 98.1% of cases had ≥1 comorbidity. Among RSV cases, the mean length of hospital stay was 10.6 days, 13.7% were admitted to the intensive care unit, 6.4% required mechanical ventilation, and 6.1% died. The mean cost per RSV case was $13 602 (Canadian dollars) but varied by age and Canadian province.
Conclusions: This study adds to the growing literature on adult RSV burden by showing considerable morbidity, mortality, and healthcare costs in hospitalized adults aged ≥50 years with ARIs such as influenza.
Keywords: Canada; RSV; adult; burden; hospitalization.
. 2023 Jun 13;10(7)
fad315.doi: 10.1093/ofid/ofad315. eCollection 2023 Jul. Leveraging Influenza Virus Surveillance From 2012 to 2015 to Characterize the Burden of Respiratory Syncytial Virus Disease in Canadian Adults ≥50 Years of Age Hospitalized With Acute Respiratory Illness
May ElSherif[SUP] 1 [/SUP], Melissa K Andrew[SUP] 1 [/SUP], Lingyun Ye[SUP] 1 [/SUP], Ardith Ambrose[SUP] 1 [/SUP], Guy Boivin[SUP] 2 [/SUP], William Bowie[SUP] 3 [/SUP], Marie-Pierre David[SUP] 4 [/SUP], Olivier Gruselle[SUP] 4 [/SUP], Scott A Halperin[SUP] 1 [/SUP], Todd F Hatchette[SUP] 1 [/SUP], Jennie Johnstone[SUP] 5 [/SUP], Kevin Katz[SUP] 6 [/SUP], Joanne M Langley[SUP] 1 [/SUP], Mark Loeb[SUP] 7 [/SUP], Donna MacKinnon-Cameron[SUP] 1 [/SUP], Anne McCarthy[SUP] 8 [/SUP], Janet E McElhaney[SUP] 9 [/SUP], Allison McGeer[SUP] 10 [/SUP], Andre Poirier[SUP] 11 [/SUP], Jean-Yves Pirçon[SUP] 4 [/SUP], Jeff Powis[SUP] 12 [/SUP], David Richardson[SUP] 13 [/SUP], Makeda Semret[SUP] 14 [/SUP], Stephanie Smith[SUP] 15 [/SUP], Daniel Smyth[SUP] 16 [/SUP], Sylvie Trottier[SUP] 2 [/SUP], Louis Valiquette[SUP] 17 [/SUP], Duncan Webster[SUP] 18 [/SUP], Shelly A McNeil[SUP] 1 [/SUP], Jason J LeBlanc[SUP] 1 [/SUP]; Serious Outcomes Surveillance (SOS) Network of the Canadian Immunization Research Network (CIRN) and the Toronto Invasive Bacterial Diseases Network (TIBDN)
Affiliations
- PMID: 37441353
- PMCID: PMC10334379
- DOI: 10.1093/ofid/ofad315
Background: Respiratory syncytial virus (RSV) disease in older adults is undercharacterized. To help inform future immunization policies, this study aimed to describe the disease burden in Canadian adults aged ≥50 years hospitalized with RSV.
Methods: Using administrative data and nasopharyngeal swabs collected from active surveillance among adults aged ≥50 years hospitalized with an acute respiratory illness (ARI) during the 2012-2013, 2013-2014, and 2014-2015 influenza seasons, RSV was identified using a respiratory virus multiplex polymerase chain reaction test to describe the associated disease burden, incidence, and healthcare costs.
Results: Of 7797 patients tested, 371 (4.8%) were RSV positive (2.2% RSV-A and 2.6% RSV-B). RSV prevalence varied by season from 4.2% to 6.2%. Respiratory virus coinfection was observed in 11.6% (43/371) of RSV cases, with influenza A being the most common. RSV hospitalization rates varied between seasons and increased with age, from 8-12 per 100 000 population in adults aged 50-59 years to 174-487 per 100 000 in adults aged ≥80 years. The median age of RSV cases was 74.9 years, 63.7% were female, and 98.1% of cases had ≥1 comorbidity. Among RSV cases, the mean length of hospital stay was 10.6 days, 13.7% were admitted to the intensive care unit, 6.4% required mechanical ventilation, and 6.1% died. The mean cost per RSV case was $13 602 (Canadian dollars) but varied by age and Canadian province.
Conclusions: This study adds to the growing literature on adult RSV burden by showing considerable morbidity, mortality, and healthcare costs in hospitalized adults aged ≥50 years with ARIs such as influenza.
Keywords: Canada; RSV; adult; burden; hospitalization.