tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 Apr 20;10(5)
fad216.
doi: 10.1093/ofid/ofad216. eCollection 2023 May. Large Diffusion of Severe Acute Respiratory Syndrome Coronavirus 2 After the Successive Epidemiological Waves, Including Omicron, in Guinea and Cameroon: Implications for Vaccine Strategies
Mamadou Saliou Kalifa Diallo[SUP] 1 2 [/SUP], Marie Amougou-Atsama[SUP] 3 [/SUP], Ahidjo Ayouba[SUP] 2 [/SUP], Cece Kpamou[SUP] 1 [/SUP], Eric Donald Mimbe Taze[SUP] 4 [/SUP], Guillaume Thaurignac[SUP] 2 [/SUP], Haby Diallo[SUP] 1 [/SUP], Nadine Boutgam Lamare[SUP] 5 [/SUP], Julie Bouillin[SUP] 2 [/SUP], Abdoul Karim Soumah[SUP] 1 [/SUP], Sébastien Awono Noah[SUP] 4 [/SUP], Emilande Guichet[SUP] 2 [/SUP], Alpha Kabinet Keita[SUP] 1 2 [/SUP], Marie Varloteaux[SUP] 4 [/SUP], Martine Peeters[SUP] 2 [/SUP], Anne-Cécile Zoung-Kanyi Bissek[SUP] 3 6 [/SUP], Abdoulaye Toure[SUP] 1 [/SUP], Eric Delaporte[SUP] 2 [/SUP], Charles Kouanfack[SUP] 4 5 7 [/SUP]
Affiliations
Background: We aimed to estimate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence among the general population in Conakry, Guinea and Yaounde, Cameroon after the coronavirus disease 2019 Omicron wave.
Methods: We conducted population-based, age-stratified seroprevalence surveys in Conakry and Yaounde (May and June 2022). We collected demographic and epidemiologic information and dried blood spot samples that were tested for SARS-CoV-2 immunoglobulin G (IgG) antibodies using recombinant nucleocapsid and spike proteins with Luminex technology.
Results: Samples were obtained from 1386 and 1425 participants in Guinea and Cameroon, respectively. The overall age-standardized SARS-CoV-2 IgG seroprevalence against spike and nucleocapsid proteins was 71.57% (95% confidence interval [CI], 67.48%-75.33%) in Guinea and 74.71% (95% CI, 71.99%-77.25%) in Cameroon. Seroprevalence increased significantly with age categories. Female participants were more likely than male participants to be seropositive. The seroprevalence in unvaccinated participants was 69.6% (95% CI, 65.5%-73.41%) in Guinea and 74.8% (95% CI, 72.04%-77.38%) in Cameroon. In multivariate analysis, only age, sex, and education were independently associated with seropositivity.
Conclusions: These findings show a high community transmission after the different epidemiological waves including Omicron, especially among people aged >40 years. In addition, our results suggest that the spread of SARS-CoV-2 has been underestimated as a significant proportion of the population has already contracted the virus and that vaccine strategies should focus on vulnerable populations.
Keywords: Cameroon; Guinea; SARS-CoV-2; population-based survey; seroprevalence.
. 2023 Apr 20;10(5)
fad216.doi: 10.1093/ofid/ofad216. eCollection 2023 May. Large Diffusion of Severe Acute Respiratory Syndrome Coronavirus 2 After the Successive Epidemiological Waves, Including Omicron, in Guinea and Cameroon: Implications for Vaccine Strategies
Mamadou Saliou Kalifa Diallo[SUP] 1 2 [/SUP], Marie Amougou-Atsama[SUP] 3 [/SUP], Ahidjo Ayouba[SUP] 2 [/SUP], Cece Kpamou[SUP] 1 [/SUP], Eric Donald Mimbe Taze[SUP] 4 [/SUP], Guillaume Thaurignac[SUP] 2 [/SUP], Haby Diallo[SUP] 1 [/SUP], Nadine Boutgam Lamare[SUP] 5 [/SUP], Julie Bouillin[SUP] 2 [/SUP], Abdoul Karim Soumah[SUP] 1 [/SUP], Sébastien Awono Noah[SUP] 4 [/SUP], Emilande Guichet[SUP] 2 [/SUP], Alpha Kabinet Keita[SUP] 1 2 [/SUP], Marie Varloteaux[SUP] 4 [/SUP], Martine Peeters[SUP] 2 [/SUP], Anne-Cécile Zoung-Kanyi Bissek[SUP] 3 6 [/SUP], Abdoulaye Toure[SUP] 1 [/SUP], Eric Delaporte[SUP] 2 [/SUP], Charles Kouanfack[SUP] 4 5 7 [/SUP]
Affiliations
- PMID: 37152188
- PMCID: PMC10157752
- DOI: 10.1093/ofid/ofad216
Background: We aimed to estimate the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) seroprevalence among the general population in Conakry, Guinea and Yaounde, Cameroon after the coronavirus disease 2019 Omicron wave.
Methods: We conducted population-based, age-stratified seroprevalence surveys in Conakry and Yaounde (May and June 2022). We collected demographic and epidemiologic information and dried blood spot samples that were tested for SARS-CoV-2 immunoglobulin G (IgG) antibodies using recombinant nucleocapsid and spike proteins with Luminex technology.
Results: Samples were obtained from 1386 and 1425 participants in Guinea and Cameroon, respectively. The overall age-standardized SARS-CoV-2 IgG seroprevalence against spike and nucleocapsid proteins was 71.57% (95% confidence interval [CI], 67.48%-75.33%) in Guinea and 74.71% (95% CI, 71.99%-77.25%) in Cameroon. Seroprevalence increased significantly with age categories. Female participants were more likely than male participants to be seropositive. The seroprevalence in unvaccinated participants was 69.6% (95% CI, 65.5%-73.41%) in Guinea and 74.8% (95% CI, 72.04%-77.38%) in Cameroon. In multivariate analysis, only age, sex, and education were independently associated with seropositivity.
Conclusions: These findings show a high community transmission after the different epidemiological waves including Omicron, especially among people aged >40 years. In addition, our results suggest that the spread of SARS-CoV-2 has been underestimated as a significant proportion of the population has already contracted the virus and that vaccine strategies should focus on vulnerable populations.
Keywords: Cameroon; Guinea; SARS-CoV-2; population-based survey; seroprevalence.