tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 May 7;8(6)
fab233.
doi: 10.1093/ofid/ofab233. eCollection 2021 Jun.
In-Hospital 30-Day Survival Among Young Adults With Coronavirus Disease 2019: A Cohort Study
Safiya Richardson[SUP] 1 2 [/SUP], Jordan Gitlin[SUP] 2 [/SUP], Zachary Kozel[SUP] 2 [/SUP], Sera Levy[SUP] 1 [/SUP], Husneara Rahman[SUP] 3 [/SUP], Jamie S Hirsch[SUP] 1 2 4 [/SUP], Thomas McGinn[SUP] 1 2 [/SUP], Michael A Diefenbach[SUP] 1 2 [/SUP]
Affiliations
Abstract
Background: Our objective was to characterize young adult patients hospitalized with coronavirus disease 2019 (COVID-19) and identify predictors of survival at 30 days.
Methods: This retrospective cohort study took place at 12 acute care hospitals in the New York City area. Patients aged 18-39 hospitalized with confirmed COVID-19 between March 1 and April 27, 2020 were included in the study. Demographic, clinical, and outcome data were extracted from electronic health record reports.
Results: A total of 1013 patients were included in the study (median age, 33 years; interquartile range [IQR], 28-36; 52% female). At the study end point, 940 (92.8%) patients were discharged alive, 18 (1.8%) remained hospitalized, 5 (0.5%) were transferred to another acute care facility, and 50 (4.9%) died. The most common comorbidities in hospitalized young adult patients were obesity (51.2%), diabetes mellitus (14.8%), and hypertension (13%). Multivariable analysis revealed that obesity (adjusted hazard ratio [aHR], 2.71; 95% confidence interval [CI], 1.28-5.73; P = .002) and Charlson comorbidity index score (aHR, 1.20; 95% CI, 1.07-1.35; P = .002) were independent predictors of in-hospital 30-day mortality.
Conclusions: Obesity was identified as the strongest negative predictor of 30-day in-hospital survival in young adults with COVID-19.
Keywords: coronavirus disease 2019 (COVID-19); mortality; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); young adults.
. 2021 May 7;8(6)
fab233.doi: 10.1093/ofid/ofab233. eCollection 2021 Jun.
In-Hospital 30-Day Survival Among Young Adults With Coronavirus Disease 2019: A Cohort Study
Safiya Richardson[SUP] 1 2 [/SUP], Jordan Gitlin[SUP] 2 [/SUP], Zachary Kozel[SUP] 2 [/SUP], Sera Levy[SUP] 1 [/SUP], Husneara Rahman[SUP] 3 [/SUP], Jamie S Hirsch[SUP] 1 2 4 [/SUP], Thomas McGinn[SUP] 1 2 [/SUP], Michael A Diefenbach[SUP] 1 2 [/SUP]
Affiliations
- PMID: 34183983
- PMCID: PMC8135976
- DOI: 10.1093/ofid/ofab233
Abstract
Background: Our objective was to characterize young adult patients hospitalized with coronavirus disease 2019 (COVID-19) and identify predictors of survival at 30 days.
Methods: This retrospective cohort study took place at 12 acute care hospitals in the New York City area. Patients aged 18-39 hospitalized with confirmed COVID-19 between March 1 and April 27, 2020 were included in the study. Demographic, clinical, and outcome data were extracted from electronic health record reports.
Results: A total of 1013 patients were included in the study (median age, 33 years; interquartile range [IQR], 28-36; 52% female). At the study end point, 940 (92.8%) patients were discharged alive, 18 (1.8%) remained hospitalized, 5 (0.5%) were transferred to another acute care facility, and 50 (4.9%) died. The most common comorbidities in hospitalized young adult patients were obesity (51.2%), diabetes mellitus (14.8%), and hypertension (13%). Multivariable analysis revealed that obesity (adjusted hazard ratio [aHR], 2.71; 95% confidence interval [CI], 1.28-5.73; P = .002) and Charlson comorbidity index score (aHR, 1.20; 95% CI, 1.07-1.35; P = .002) were independent predictors of in-hospital 30-day mortality.
Conclusions: Obesity was identified as the strongest negative predictor of 30-day in-hospital survival in young adults with COVID-19.
Keywords: coronavirus disease 2019 (COVID-19); mortality; severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); young adults.