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Open Forum Infect Dis . Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study

tetano

tetano

Editor, Senior Moderator
Open Forum Infect Dis


. 2022 Oct 6;9(10):ofac526.
doi: 10.1093/ofid/ofac526. eCollection 2022 Oct.
Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study


Arjun Chandna[SUP] 1 2 [/SUP], Raman Mahajan[SUP] 3 [/SUP], Priyanka Gautam[SUP] 4 [/SUP], Lazaro Mwandigha[SUP] 5 [/SUP], PRIORITISE Study Investigators; Pragya Kumar[SUP] 6 [/SUP], George M Varghese[SUP] 4 [/SUP], Constantinos Koshiaris[SUP] 5 [/SUP], Yoel Lubell[SUP] 2 7 [/SUP], Sakib Burza[SUP] 3 8 [/SUP]



Affiliations

Abstract

Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)-1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases.

Keywords: COVID-19; host biomarker; prognosis.
 
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