tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2020 May 26;7(8)
faa181.
doi: 10.1093/ofid/ofaa181. eCollection 2020 Aug.
Effects of Prior Influenza Exposure on Immunogenicity of Influenza Vaccine
Jia-Qian Cao[SUP] 1 [/SUP], Peng-Fei Jin[SUP] 2 [/SUP], Jing-Xin Li[SUP] 2 [/SUP], Zhao-Zhun Zeng[SUP] 3 [/SUP], Li Zhang[SUP] 2 [/SUP], Fan-Yue Meng[SUP] 2 [/SUP], Kai Chu[SUP] 2 [/SUP], Yuan-Yuan Wang[SUP] 1 [/SUP], Feng-Cai Zhu[SUP] 1 4 5 [/SUP]
Affiliations
Abstract
Background: In this study, we investigated the effects of prior influenza exposure on vaccine-elicited humor immune responses to circulating influenza variants.
Method: We randomly selected 360 participants in previous clinical trials stratified by age. Blood samples were collected and tested by hemagglutination-inhibition tests during the 2015-2016 influenza seasons in China. The antigenic map was plotted and antigenic distance was calculated.
Results: Subjects with H1-priming had higher cross-reactive antibodies titers against A/JiangsuTinghu/11019/2015(H3N2) compared with subjects with B-priming did (P [SUB]adjusted[/SUB] = .038). Subjects with H1-priming also had higher cross-reactive antibodies titers against A/Jiangsu Qinhuai/11059/2015(H3N2) than subjects with both H1 and B priming (P [SUB]adjusted[/SUB] = .036). Nevertheless, subjects with no H1 and B-priming had higher cross-reactive antibodies titers against A/Jiangsu Qinhuai/11059/2015(H3N2) than subjects with both H1 and B priming (P [SUB]adjusted[/SUB] = .012). Antigenic distance was well matched with serological results. Moeover, age-specific differences in human postvaccination responses against the identical circulating strain was noted. In addition, children had the most cross-reactive response to both H3N2 and B-yamagata subtypes.
Conclusions: Our results suggest that prior exposure to H1 or B influenza virus may influence cross-reactivity of H3-specific postvaccination responses and consequently could influence the vaccine effectiveness. Our findings also support that there are age-specific differences in human postvaccination responses.
Keywords: cross-reactivity; seasonal influenza; vaccine.
. 2020 May 26;7(8)
faa181.doi: 10.1093/ofid/ofaa181. eCollection 2020 Aug.
Effects of Prior Influenza Exposure on Immunogenicity of Influenza Vaccine
Jia-Qian Cao[SUP] 1 [/SUP], Peng-Fei Jin[SUP] 2 [/SUP], Jing-Xin Li[SUP] 2 [/SUP], Zhao-Zhun Zeng[SUP] 3 [/SUP], Li Zhang[SUP] 2 [/SUP], Fan-Yue Meng[SUP] 2 [/SUP], Kai Chu[SUP] 2 [/SUP], Yuan-Yuan Wang[SUP] 1 [/SUP], Feng-Cai Zhu[SUP] 1 4 5 [/SUP]
Affiliations
- PMID: 32818136
- PMCID: PMC7423295
- DOI: 10.1093/ofid/ofaa181
Abstract
Background: In this study, we investigated the effects of prior influenza exposure on vaccine-elicited humor immune responses to circulating influenza variants.
Method: We randomly selected 360 participants in previous clinical trials stratified by age. Blood samples were collected and tested by hemagglutination-inhibition tests during the 2015-2016 influenza seasons in China. The antigenic map was plotted and antigenic distance was calculated.
Results: Subjects with H1-priming had higher cross-reactive antibodies titers against A/JiangsuTinghu/11019/2015(H3N2) compared with subjects with B-priming did (P [SUB]adjusted[/SUB] = .038). Subjects with H1-priming also had higher cross-reactive antibodies titers against A/Jiangsu Qinhuai/11059/2015(H3N2) than subjects with both H1 and B priming (P [SUB]adjusted[/SUB] = .036). Nevertheless, subjects with no H1 and B-priming had higher cross-reactive antibodies titers against A/Jiangsu Qinhuai/11059/2015(H3N2) than subjects with both H1 and B priming (P [SUB]adjusted[/SUB] = .012). Antigenic distance was well matched with serological results. Moeover, age-specific differences in human postvaccination responses against the identical circulating strain was noted. In addition, children had the most cross-reactive response to both H3N2 and B-yamagata subtypes.
Conclusions: Our results suggest that prior exposure to H1 or B influenza virus may influence cross-reactivity of H3-specific postvaccination responses and consequently could influence the vaccine effectiveness. Our findings also support that there are age-specific differences in human postvaccination responses.
Keywords: cross-reactivity; seasonal influenza; vaccine.