tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 Jul 29;8(8)
fab393.
doi: 10.1093/ofid/ofab393. eCollection 2021 Aug.
Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease
Michael J Peluso[SUP] 1 [/SUP], Sadie E Munter[SUP] 2 [/SUP], Kara L Lynch[SUP] 3 [/SUP], Cassandra Yun[SUP] 3 [/SUP], Leonel Torres[SUP] 2 [/SUP], Nikita S Iyer[SUP] 2 [/SUP], Joanna Donatelli[SUP] 2 [/SUP], Lindsay Ryan[SUP] 4 [/SUP], Amelia N Deitchman[SUP] 5 [/SUP], Steven G Deeks[SUP] 1 [/SUP], Rachel L Rutishauser[SUP] 2 [/SUP], Timothy J Henrich[SUP] 2 [/SUP]
Affiliations
Abstract
We report a patient with connective tissue disease who developed modest severe acute respiratory syndrome coronavirus 2 receptor binding domain-specific antibody levels and a lack of neutralization capacity, despite having received 3 mRNA coronavirus disease 2019 vaccines and holding anti-B-cell therapy for >7 months before vaccination. The patient developed virus-specific T-cell responses.
Keywords: COVID-19 vaccine; SARS-CoV-2; T-cell immunity; neutralizing antibodies; rheumatological disease.
. 2021 Jul 29;8(8)
fab393.doi: 10.1093/ofid/ofab393. eCollection 2021 Aug.
Discordant Virus-Specific Antibody Levels, Antibody Neutralization Capacity, and T-cell Responses Following 3 Doses of SARS-CoV-2 Vaccination in a Patient With Connective Tissue Disease
Michael J Peluso[SUP] 1 [/SUP], Sadie E Munter[SUP] 2 [/SUP], Kara L Lynch[SUP] 3 [/SUP], Cassandra Yun[SUP] 3 [/SUP], Leonel Torres[SUP] 2 [/SUP], Nikita S Iyer[SUP] 2 [/SUP], Joanna Donatelli[SUP] 2 [/SUP], Lindsay Ryan[SUP] 4 [/SUP], Amelia N Deitchman[SUP] 5 [/SUP], Steven G Deeks[SUP] 1 [/SUP], Rachel L Rutishauser[SUP] 2 [/SUP], Timothy J Henrich[SUP] 2 [/SUP]
Affiliations
- PMID: 34395717
- PMCID: PMC8344490
- DOI: 10.1093/ofid/ofab393
Abstract
We report a patient with connective tissue disease who developed modest severe acute respiratory syndrome coronavirus 2 receptor binding domain-specific antibody levels and a lack of neutralization capacity, despite having received 3 mRNA coronavirus disease 2019 vaccines and holding anti-B-cell therapy for >7 months before vaccination. The patient developed virus-specific T-cell responses.
Keywords: COVID-19 vaccine; SARS-CoV-2; T-cell immunity; neutralizing antibodies; rheumatological disease.