tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 Nov 17;10(12)
fad579.
doi: 10.1093/ofid/ofad579. eCollection 2023 Dec. Decreased Self-reported Physical Fitness Following SARS-CoV-2 Infection and the Impact of Vaccine Boosters in a Cohort Study
Stephanie A Richard[SUP] 1 2 [/SUP], Ann I Scher[SUP] 3 [/SUP], Jennifer Rusiecki[SUP] 3 [/SUP], Celia Byrne[SUP] 3 [/SUP], Catherine M Berjohn[SUP] 1 3 4 [/SUP], Anthony C Fries[SUP] 5 [/SUP], Tahaniyat Lalani[SUP] 1 2 6 [/SUP], Alfred G Smith[SUP] 6 [/SUP], Rupal M Mody[SUP] 7 [/SUP], Anuradha Ganesan[SUP] 1 2 8 [/SUP], Nikhil Huprikar[SUP] 3 8 [/SUP], Rhonda E Colombo[SUP] 1 2 3 9 [/SUP], Christopher J Colombo[SUP] 3 9 [/SUP], Christina Schofield[SUP] 9 [/SUP], David A Lindholm[SUP] 3 10 [/SUP], Katrin Mende[SUP] 1 2 10 [/SUP], Michael J Morris[SUP] 10 [/SUP], Milissa U Jones[SUP] 11 [/SUP], Ryan Flanagan[SUP] 11 [/SUP], Derek T Larson[SUP] 3 4 12 [/SUP], Evan C Ewers[SUP] 3 12 [/SUP], Samantha E Bazan[SUP] 13 [/SUP], David Saunders[SUP] 3 [/SUP], Ryan C Maves[SUP] 14 [/SUP], Jeffrey Livezey[SUP] 15 [/SUP], Carlos J Maldonado[SUP] 16 [/SUP], Margaret Sanchez Edwards[SUP] 1 2 [/SUP], Julia S Rozman[SUP] 1 2 [/SUP], Robert J O'Connell[SUP] 1 [/SUP], Mark P Simons[SUP] 1 [/SUP], David R Tribble[SUP] 1 [/SUP], Brian K Agan[SUP] 1 2 [/SUP], Timothy H Burgess[SUP] 1 [/SUP], Simon D Pollett[SUP] 1 2 [/SUP]; EPICC COVID-19 Cohort Study Group
Collaborators, Affiliations
Background: The long-term effects of coronavirus disease 2019 (COVID-19) on physical fitness are unclear, and the impact of vaccination on that relationship is uncertain.
Methods: We compared survey responses in a 1-year study of US military service members with (n = 1923) and without (n = 1591) a history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We fit Poisson regression models to estimate the association between history of SARS-CoV-2 infection and fitness impairment, adjusting for time since infection, demographics, and baseline health.
Results: The participants in this analysis were primarily young adults aged 18-39 years (75%), and 71.5% were male. Participants with a history of SARS-CoV-2 infection were more likely to report difficulty exercising (38.7% vs 18.4%; P < .01), difficulty performing daily activities (30.4% vs 12.7%; P < .01), and decreased fitness test (FT) scores (42.7% vs 26.2%; P < .01) than those without a history of infection. SARS-CoV-2-infected participants were at higher risk of these outcomes after adjusting for other factors (unvaccinated: exercising: adjusted risk ratio [aRR], 3.99; 95% CI, 3.36-4.73; activities: aRR, 5.02; 95% CI, 4.09-6.16; FT affected: aRR, 2.55; 95% CI, 2.19-2.98). Among SARS-CoV-2-positive participants, full vaccination before infection was associated with a lower risk of post-COVID-19 fitness impairment (fully vaccinated: exercise: aRR, 0.81; 95% CI, 0.70-0.95; activities: aRR, 0.76; 95% CI, 0.64-0.91; FT: aRR, 0.87; 95% CI, 0.76-1.00; boosted: exercise: aRR, 0.62; 95% CI, 0.51-0.74; activities: aRR, 0.52; 95% CI, 0.41-0.65; FT: aRR, 0.59; 95% CI, 0.49-0.70).
Conclusions: In this study of generally young, healthy military service members, SARS-CoV-2 infection was associated with lower self-reported fitness and exercise capacity; vaccination and boosting were associated with lower risk of self-reported fitness loss.
Keywords: COVID-19; fitness; long COVID.
. 2023 Nov 17;10(12)
fad579.doi: 10.1093/ofid/ofad579. eCollection 2023 Dec. Decreased Self-reported Physical Fitness Following SARS-CoV-2 Infection and the Impact of Vaccine Boosters in a Cohort Study
Stephanie A Richard[SUP] 1 2 [/SUP], Ann I Scher[SUP] 3 [/SUP], Jennifer Rusiecki[SUP] 3 [/SUP], Celia Byrne[SUP] 3 [/SUP], Catherine M Berjohn[SUP] 1 3 4 [/SUP], Anthony C Fries[SUP] 5 [/SUP], Tahaniyat Lalani[SUP] 1 2 6 [/SUP], Alfred G Smith[SUP] 6 [/SUP], Rupal M Mody[SUP] 7 [/SUP], Anuradha Ganesan[SUP] 1 2 8 [/SUP], Nikhil Huprikar[SUP] 3 8 [/SUP], Rhonda E Colombo[SUP] 1 2 3 9 [/SUP], Christopher J Colombo[SUP] 3 9 [/SUP], Christina Schofield[SUP] 9 [/SUP], David A Lindholm[SUP] 3 10 [/SUP], Katrin Mende[SUP] 1 2 10 [/SUP], Michael J Morris[SUP] 10 [/SUP], Milissa U Jones[SUP] 11 [/SUP], Ryan Flanagan[SUP] 11 [/SUP], Derek T Larson[SUP] 3 4 12 [/SUP], Evan C Ewers[SUP] 3 12 [/SUP], Samantha E Bazan[SUP] 13 [/SUP], David Saunders[SUP] 3 [/SUP], Ryan C Maves[SUP] 14 [/SUP], Jeffrey Livezey[SUP] 15 [/SUP], Carlos J Maldonado[SUP] 16 [/SUP], Margaret Sanchez Edwards[SUP] 1 2 [/SUP], Julia S Rozman[SUP] 1 2 [/SUP], Robert J O'Connell[SUP] 1 [/SUP], Mark P Simons[SUP] 1 [/SUP], David R Tribble[SUP] 1 [/SUP], Brian K Agan[SUP] 1 2 [/SUP], Timothy H Burgess[SUP] 1 [/SUP], Simon D Pollett[SUP] 1 2 [/SUP]; EPICC COVID-19 Cohort Study Group
Collaborators, Affiliations
- PMID: 38130596
- PMCID: PMC10733205
- DOI: 10.1093/ofid/ofad579
Background: The long-term effects of coronavirus disease 2019 (COVID-19) on physical fitness are unclear, and the impact of vaccination on that relationship is uncertain.
Methods: We compared survey responses in a 1-year study of US military service members with (n = 1923) and without (n = 1591) a history of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We fit Poisson regression models to estimate the association between history of SARS-CoV-2 infection and fitness impairment, adjusting for time since infection, demographics, and baseline health.
Results: The participants in this analysis were primarily young adults aged 18-39 years (75%), and 71.5% were male. Participants with a history of SARS-CoV-2 infection were more likely to report difficulty exercising (38.7% vs 18.4%; P < .01), difficulty performing daily activities (30.4% vs 12.7%; P < .01), and decreased fitness test (FT) scores (42.7% vs 26.2%; P < .01) than those without a history of infection. SARS-CoV-2-infected participants were at higher risk of these outcomes after adjusting for other factors (unvaccinated: exercising: adjusted risk ratio [aRR], 3.99; 95% CI, 3.36-4.73; activities: aRR, 5.02; 95% CI, 4.09-6.16; FT affected: aRR, 2.55; 95% CI, 2.19-2.98). Among SARS-CoV-2-positive participants, full vaccination before infection was associated with a lower risk of post-COVID-19 fitness impairment (fully vaccinated: exercise: aRR, 0.81; 95% CI, 0.70-0.95; activities: aRR, 0.76; 95% CI, 0.64-0.91; FT: aRR, 0.87; 95% CI, 0.76-1.00; boosted: exercise: aRR, 0.62; 95% CI, 0.51-0.74; activities: aRR, 0.52; 95% CI, 0.41-0.65; FT: aRR, 0.59; 95% CI, 0.49-0.70).
Conclusions: In this study of generally young, healthy military service members, SARS-CoV-2 infection was associated with lower self-reported fitness and exercise capacity; vaccination and boosting were associated with lower risk of self-reported fitness loss.
Keywords: COVID-19; fitness; long COVID.