tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2023 Dec 29;11(1)
fad686.
doi: 10.1093/ofid/ofad686. eCollection 2024 Jan. COVID-19 Convalescent Plasma Therapy: Long-term Implications
Hyunah Yoon[SUP] 1 [/SUP], Yi Li[SUP] 2 [/SUP], Keith S Goldfeld[SUP] 2 [/SUP], Gia F Cobb[SUP] 3 [/SUP], Caroline L Sturm-Reganato[SUP] 3 [/SUP], Luis Ostrosky-Zeichner[SUP] 4 [/SUP], Dushyantha T Jayaweera[SUP] 5 6 [/SUP], Julie V Philley[SUP] 7 [/SUP], Mahalia S Desruisseaux[SUP] 8 [/SUP], Marla J Keller[SUP] 1 9 [/SUP], Judith S Hochman[SUP] 10 [/SUP], Liise-Anne Pirofski[SUP] 1 11 [/SUP], Mila B Ortigoza[SUP] 12 13 [/SUP]; CONTAIN-Extend Study Group
Collaborators, Affiliations
Background: The long-term effect of coronavirus disease 2019 (COVID-19) acute treatments on postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) is unknown. The CONTAIN-Extend study explores the long-term impact of COVID-19 convalescent plasma (CCP) therapy on postacute sequelae of SARS-CoV-2 infection (PASC) symptoms and general health 18 months following hospitalization.
Methods: The CONTAIN-Extend study examined 281 participants from the original CONTAIN COVID-19 trial (CONTAIN-RCT, NCT04364737) at 18 months post-hospitalization for acute COVID-19. Symptom surveys, global health assessments, and biospecimen collection were performed from November 2021 to October 2022. Multivariable logistic and linear regression estimated associations between the randomization arms and self-reported symptoms and Patient-Reported Outcomes Measurement Information System (PROMIS) scores and adjusted for covariables, including age, sex, race/ethnicity, disease severity, and CONTAIN enrollment quarter and sites.
Results: There were no differences in symptoms or PROMIS scores between CCP and placebo (adjusted odds ratio [aOR] of general symptoms, 0.95; 95% CI, 0.54-1.67). However, females (aOR, 3.01; 95% CI, 1.73-5.34), those 45-64 years (aOR, 2.55; 95% CI, 1.14-6.23), and April-June 2020 enrollees (aOR, 2.39; 95% CI, 1.10-5.19) were more likely to report general symptoms and have poorer PROMIS physical health scores than their respective reference groups. Hispanic participants (difference, -3.05; 95% CI, -5.82 to -0.27) and Black participants (-4.48; 95% CI, -7.94 to -1.02) had poorer PROMIS physical health than White participants.
Conclusions: CCP demonstrated no lasting effect on PASC symptoms or overall health in comparison to the placebo. This study underscores the significance of demographic factors, including sex, age, and timing of acute infection, in influencing symptom reporting 18 months after acute hypoxic COVID-19 hospitalization.
Keywords: COVID-19 convalescent plasma; PASC; Patient-Reported Outcomes Measurement Information System; acute hypoxic COVID-19; long COVID.
. 2023 Dec 29;11(1)
fad686.doi: 10.1093/ofid/ofad686. eCollection 2024 Jan. COVID-19 Convalescent Plasma Therapy: Long-term Implications
Hyunah Yoon[SUP] 1 [/SUP], Yi Li[SUP] 2 [/SUP], Keith S Goldfeld[SUP] 2 [/SUP], Gia F Cobb[SUP] 3 [/SUP], Caroline L Sturm-Reganato[SUP] 3 [/SUP], Luis Ostrosky-Zeichner[SUP] 4 [/SUP], Dushyantha T Jayaweera[SUP] 5 6 [/SUP], Julie V Philley[SUP] 7 [/SUP], Mahalia S Desruisseaux[SUP] 8 [/SUP], Marla J Keller[SUP] 1 9 [/SUP], Judith S Hochman[SUP] 10 [/SUP], Liise-Anne Pirofski[SUP] 1 11 [/SUP], Mila B Ortigoza[SUP] 12 13 [/SUP]; CONTAIN-Extend Study Group
Collaborators, Affiliations
- PMID: 38269049
- PMCID: PMC10807994
- DOI: 10.1093/ofid/ofad686
Background: The long-term effect of coronavirus disease 2019 (COVID-19) acute treatments on postacute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC) is unknown. The CONTAIN-Extend study explores the long-term impact of COVID-19 convalescent plasma (CCP) therapy on postacute sequelae of SARS-CoV-2 infection (PASC) symptoms and general health 18 months following hospitalization.
Methods: The CONTAIN-Extend study examined 281 participants from the original CONTAIN COVID-19 trial (CONTAIN-RCT, NCT04364737) at 18 months post-hospitalization for acute COVID-19. Symptom surveys, global health assessments, and biospecimen collection were performed from November 2021 to October 2022. Multivariable logistic and linear regression estimated associations between the randomization arms and self-reported symptoms and Patient-Reported Outcomes Measurement Information System (PROMIS) scores and adjusted for covariables, including age, sex, race/ethnicity, disease severity, and CONTAIN enrollment quarter and sites.
Results: There were no differences in symptoms or PROMIS scores between CCP and placebo (adjusted odds ratio [aOR] of general symptoms, 0.95; 95% CI, 0.54-1.67). However, females (aOR, 3.01; 95% CI, 1.73-5.34), those 45-64 years (aOR, 2.55; 95% CI, 1.14-6.23), and April-June 2020 enrollees (aOR, 2.39; 95% CI, 1.10-5.19) were more likely to report general symptoms and have poorer PROMIS physical health scores than their respective reference groups. Hispanic participants (difference, -3.05; 95% CI, -5.82 to -0.27) and Black participants (-4.48; 95% CI, -7.94 to -1.02) had poorer PROMIS physical health than White participants.
Conclusions: CCP demonstrated no lasting effect on PASC symptoms or overall health in comparison to the placebo. This study underscores the significance of demographic factors, including sex, age, and timing of acute infection, in influencing symptom reporting 18 months after acute hypoxic COVID-19 hospitalization.
Keywords: COVID-19 convalescent plasma; PASC; Patient-Reported Outcomes Measurement Information System; acute hypoxic COVID-19; long COVID.