tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2022 May 1;9(7)
fac222.
doi: 10.1093/ofid/ofac222. eCollection 2022 Jul.
Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More?
Nicole H Tobin[SUP] 1 [/SUP], Otto O Yang[SUP] 2 [/SUP]
Affiliations
Abstract
The lower efficacy of the COVID-19 mRNA vaccines in 5-11 year old children was unexpected. Neutralizing antibody titers elicited by the vaccines in children, adolescents, and young adults suggest that the lower efficacy is not due to the lower dosage. Confirming the efficacy of these vaccines in children, determining if mRNA vaccination strategies are less effective in younger children, as well as optimizing the dosage, dosing intervals, and number of doses needed in children, adolescents, and young adults are critical to improve vaccination strategies for these populations going forward.
Keywords: Boosters; COVID-19; COVID-19 vaccination; Covid-19 vaccination associated myocarditis; Dosage; Dosing intervals; Myocarditis; adolescents; children; young adults.
. 2022 May 1;9(7)
fac222.doi: 10.1093/ofid/ofac222. eCollection 2022 Jul.
Coronavirus Disease 2019 Vaccine Dosage in Children, Adolescents, and Young Adults: Is Less More?
Nicole H Tobin[SUP] 1 [/SUP], Otto O Yang[SUP] 2 [/SUP]
Affiliations
- PMID: 35821728
- PMCID: PMC9272428
- DOI: 10.1093/ofid/ofac222
Abstract
The lower efficacy of the COVID-19 mRNA vaccines in 5-11 year old children was unexpected. Neutralizing antibody titers elicited by the vaccines in children, adolescents, and young adults suggest that the lower efficacy is not due to the lower dosage. Confirming the efficacy of these vaccines in children, determining if mRNA vaccination strategies are less effective in younger children, as well as optimizing the dosage, dosing intervals, and number of doses needed in children, adolescents, and young adults are critical to improve vaccination strategies for these populations going forward.
Keywords: Boosters; COVID-19; COVID-19 vaccination; Covid-19 vaccination associated myocarditis; Dosage; Dosing intervals; Myocarditis; adolescents; children; young adults.