tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2020 Oct 18;7(11)
faa394.
doi: 10.1093/ofid/ofaa394. eCollection 2020 Nov.
Clinical Cutaneous Features of Patients Infected With SARS-CoV-2 Hospitalized for Pneumonia: A Cross-sectional Study
H?l?ne Mascitti[SUP] 1 [/SUP], Benjamin Bonsang[SUP] 2 [/SUP], Aur?lien Dinh[SUP] 1 [/SUP], Florence Assan[SUP] 1 [/SUP], V?ronique Perronne[SUP] 1 [/SUP], Thibault Leblanc[SUP] 1 [/SUP], Clara Duran[SUP] 1 [/SUP], Fr?d?rique Bouchand[SUP] 3 [/SUP], Morgan Matt[SUP] 1 [/SUP], Aur?lie Le Gal[SUP] 1 [/SUP], Julia N'guyen Van Thanh[SUP] 1 [/SUP], Aymeric Lanore[SUP] 1 [/SUP], Louis Jacob[SUP] 1 [/SUP], Nicolas Kiavue[SUP] 1 [/SUP], Soline Sim?on[SUP] 1 [/SUP], Simon Bessis[SUP] 1 [/SUP], Pierre de Truchis[SUP] 1 [/SUP], St?phanie Landowski[SUP] 1 [/SUP], Benjamin Davido[SUP] 1 [/SUP], Fr?d?rique Moreau[SUP] 4 [/SUP], Marie-Anne Rameix-Welti[SUP] 4 [/SUP], Elyanne Gault[SUP] 4 [/SUP], Jean-Louis Gaillard[SUP] 4 [/SUP], Anne-Laure Roux[SUP] 4 [/SUP], Val?rie Sivadon-Tardy[SUP] 4 [/SUP], Elsa Salomon[SUP] 4 [/SUP], Faten El Sayed[SUP] 4 [/SUP], Robert Carlier[SUP] 5 [/SUP], Jean-Fran?ois Emile[SUP] 2 [/SUP], Christian Perronne[SUP] 1 [/SUP], Isabelle Bourgault-Villada[SUP] 6 [/SUP]
Affiliations
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a current pandemic worldwide. This virus can reach all organs and disturbs the immune system, leading to a cytokine storm in severe forms. We aimed to report cutaneous features among coronavirus disease 2019 (COVID-19) hospitalized patients.
Methods: We performed a cross-sectional study on 1 given day among all patients hospitalized in acute care for COVID-19 and included all patients with cutaneous features. Follow-up 48 hours later was obtained.
Results: Among 59 adult patients hospitalized on the day of the study in an infectious diseases ward for SARS-CoV-2 infection who were confirmed by molecular assay and/or radiological findings (computed tomography scan), 40 were included. Several cutaneous manifestations were found: macular exanthema (80%), face edema (32%), livedo (13%), urticarial rash (8%), purpura (5%), oral lichenoid lesions (33%), and conjunctivitis (18%). Cutaneous biopsy was performed in 17 patients. Histological findings showed mast cell hyperplasia (100%), superficial perivascular infiltrate of lymphocytes (94%), and superficial edema (47%) consistent with capillary leak.
Conclusions: Various dermatological signs can be encountered during COVID-19. A macular rash was the most frequent. All cutaneous features could be related to a vascular leak process.
Keywords: COVID-19; dermatology; exanthema; pandemics; pneumonia.
. 2020 Oct 18;7(11)
faa394.doi: 10.1093/ofid/ofaa394. eCollection 2020 Nov.
Clinical Cutaneous Features of Patients Infected With SARS-CoV-2 Hospitalized for Pneumonia: A Cross-sectional Study
H?l?ne Mascitti[SUP] 1 [/SUP], Benjamin Bonsang[SUP] 2 [/SUP], Aur?lien Dinh[SUP] 1 [/SUP], Florence Assan[SUP] 1 [/SUP], V?ronique Perronne[SUP] 1 [/SUP], Thibault Leblanc[SUP] 1 [/SUP], Clara Duran[SUP] 1 [/SUP], Fr?d?rique Bouchand[SUP] 3 [/SUP], Morgan Matt[SUP] 1 [/SUP], Aur?lie Le Gal[SUP] 1 [/SUP], Julia N'guyen Van Thanh[SUP] 1 [/SUP], Aymeric Lanore[SUP] 1 [/SUP], Louis Jacob[SUP] 1 [/SUP], Nicolas Kiavue[SUP] 1 [/SUP], Soline Sim?on[SUP] 1 [/SUP], Simon Bessis[SUP] 1 [/SUP], Pierre de Truchis[SUP] 1 [/SUP], St?phanie Landowski[SUP] 1 [/SUP], Benjamin Davido[SUP] 1 [/SUP], Fr?d?rique Moreau[SUP] 4 [/SUP], Marie-Anne Rameix-Welti[SUP] 4 [/SUP], Elyanne Gault[SUP] 4 [/SUP], Jean-Louis Gaillard[SUP] 4 [/SUP], Anne-Laure Roux[SUP] 4 [/SUP], Val?rie Sivadon-Tardy[SUP] 4 [/SUP], Elsa Salomon[SUP] 4 [/SUP], Faten El Sayed[SUP] 4 [/SUP], Robert Carlier[SUP] 5 [/SUP], Jean-Fran?ois Emile[SUP] 2 [/SUP], Christian Perronne[SUP] 1 [/SUP], Isabelle Bourgault-Villada[SUP] 6 [/SUP]
Affiliations
- PMID: 33204745
- PMCID: PMC7650967
- DOI: 10.1093/ofid/ofaa394
Abstract
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of a current pandemic worldwide. This virus can reach all organs and disturbs the immune system, leading to a cytokine storm in severe forms. We aimed to report cutaneous features among coronavirus disease 2019 (COVID-19) hospitalized patients.
Methods: We performed a cross-sectional study on 1 given day among all patients hospitalized in acute care for COVID-19 and included all patients with cutaneous features. Follow-up 48 hours later was obtained.
Results: Among 59 adult patients hospitalized on the day of the study in an infectious diseases ward for SARS-CoV-2 infection who were confirmed by molecular assay and/or radiological findings (computed tomography scan), 40 were included. Several cutaneous manifestations were found: macular exanthema (80%), face edema (32%), livedo (13%), urticarial rash (8%), purpura (5%), oral lichenoid lesions (33%), and conjunctivitis (18%). Cutaneous biopsy was performed in 17 patients. Histological findings showed mast cell hyperplasia (100%), superficial perivascular infiltrate of lymphocytes (94%), and superficial edema (47%) consistent with capillary leak.
Conclusions: Various dermatological signs can be encountered during COVID-19. A macular rash was the most frequent. All cutaneous features could be related to a vascular leak process.
Keywords: COVID-19; dermatology; exanthema; pandemics; pneumonia.