tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 Jul 16;8(8)
fab385.
doi: 10.1093/ofid/ofab385. eCollection 2021 Aug.
Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019
Emma D Bainbridge[SUP] 1 [/SUP], Priscilla Y Hsue[SUP] 2 [/SUP], Jonathan H Esensten[SUP] 3 [/SUP], Kara L Lynch[SUP] 3 [/SUP], Carolyn M Hendrickson[SUP] 4 [/SUP], Sarah B Doernberg[SUP] 1 [/SUP], Monica Fung[SUP] 1 [/SUP], Peter Chin-Hong[SUP] 1 [/SUP], Clara Di Germanio[SUP] 5 [/SUP], Philip J Norris[SUP] 3 5 [/SUP], Graham Simmons[SUP] 3 5 [/SUP], David V Glidden[SUP] 6 [/SUP], Anne F Luetkemeyer[SUP] 7 [/SUP]
Affiliations
Abstract
We characterized the antibody composition of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) and the immunologic responses of hospitalized COVID-19 patients after receiving CCP or nonimmune fresh frozen plasma. Despite selection of CCP with significantly higher total immunoglobulin G than recipients, neutralizing antibody levels did not differ between donor plasma and CCP recipients.
Keywords: COVID-19; SARS-CoV-2; antibody avidity; convalescent plasma; neutralizing antibody.
. 2021 Jul 16;8(8)
fab385.doi: 10.1093/ofid/ofab385. eCollection 2021 Aug.
Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019
Emma D Bainbridge[SUP] 1 [/SUP], Priscilla Y Hsue[SUP] 2 [/SUP], Jonathan H Esensten[SUP] 3 [/SUP], Kara L Lynch[SUP] 3 [/SUP], Carolyn M Hendrickson[SUP] 4 [/SUP], Sarah B Doernberg[SUP] 1 [/SUP], Monica Fung[SUP] 1 [/SUP], Peter Chin-Hong[SUP] 1 [/SUP], Clara Di Germanio[SUP] 5 [/SUP], Philip J Norris[SUP] 3 5 [/SUP], Graham Simmons[SUP] 3 5 [/SUP], David V Glidden[SUP] 6 [/SUP], Anne F Luetkemeyer[SUP] 7 [/SUP]
Affiliations
- PMID: 34405093
- PMCID: PMC8344822
- DOI: 10.1093/ofid/ofab385
Abstract
We characterized the antibody composition of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) and the immunologic responses of hospitalized COVID-19 patients after receiving CCP or nonimmune fresh frozen plasma. Despite selection of CCP with significantly higher total immunoglobulin G than recipients, neutralizing antibody levels did not differ between donor plasma and CCP recipients.
Keywords: COVID-19; SARS-CoV-2; antibody avidity; convalescent plasma; neutralizing antibody.