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Open Forum Infect Dis . Assessment of Cross-Reactive Neutralizing Antibodies Induction Against H5N1 Clade 2.3.4.4b by Prior Seasonal Influenza Immu

tetano

tetano

Editor, Senior Moderator
Open Forum Infect Dis


. 2025 Aug 20;12(8):ofaf463.
doi: 10.1093/ofid/ofaf463. eCollection 2025 Aug. Assessment of Cross-Reactive Neutralizing Antibodies Induction Against H5N1 Clade 2.3.4.4b by Prior Seasonal Influenza Immunization in Retail Workers

Andrea Arroyave[SUP] 1 2 [/SUP], Henintsoa Rabezanahary[SUP] 1 2 [/SUP], Aude Wantchecon[SUP] 1 2 [/SUP], Vonintsoa Lalaina Rahajamanana[SUP] 1 2 [/SUP], Ahmed Sahli[SUP] 1 2 [/SUP], Mathieu Thériault[SUP] 1 2 [/SUP], Denis Boudreau[SUP] 3 [/SUP], Caroline Gilbert[SUP] 1 2 [/SUP], Sylvie Trottier[SUP] 1 2 [/SUP], Mariana Baz[SUP] 1 2 [/SUP]



Affiliations
Abstract

This study evaluated whether immunity from seasonal influenza induces cross-reactive antibodies against recent avian and bovine H5N1 strains in serum from retail workers. Despite strong neutralizing activity against seasonal strains, no cross-reactivity against H5N1 was detected, emphasizing the need to assess broader immune responses and targeted vaccines for H5N1 viruses.

Keywords: H5N1; cross-reactivity; immunity; influenza; neutralization.

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