tetano
Editor, Senior Moderator
Open Forum Infect Dis
. 2021 Sep 18;8(10)
fab472.
doi: 10.1093/ofid/ofab472. eCollection 2021 Oct.
Application of a Serial Antigen-Based Testing Strategy for Severe Acute Respiratory Syndrome Coronavirus 2 and Student Adherence in a University Setting: Wisconsin, October-November 2020
John Paul Bigouette[SUP] 1 2 [/SUP], Laura Ford[SUP] 1 2 [/SUP], Ian Pray[SUP] 1 2 3 [/SUP], Kimberly Langolf[SUP] 4 [/SUP], Juliana Kahrs[SUP] 4 [/SUP], Tara Zochert[SUP] 4 [/SUP], Jacqueline E Tate[SUP] 1 [/SUP], Douglas Gieryn[SUP] 5 [/SUP], Hannah L Kirking[SUP] 1 [/SUP], Ryan Westergaard[SUP] 3 6 [/SUP], Marie E Killerby[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Serial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing has been implemented at institutions of higher education (IHEs) and other settings. Testing strategies can include algorithms specifying confirmatory reverse-transcription polymerase chain reaction (RT-PCR) testing after an antigen test. It is unknown how testing strategies perform detecting SARS-CoV-2, including individual adherence to serial testing requirements.
Methods: Student serial testing adherence was defined as completing ≥80% of weekly tests from October 5, 2020 to November 14, 2020 and evaluated using logistic regression. Medical records were reviewed for all positive antigen test encounters and 10% of daily negative antigen test encounters during October 19-November 30, 2020. Results were used to estimate the proportion of individuals requiring only antigen tests, requiring and completing RT-PCR testing, and associated costs of tests.
Results: Two thirds (66.5%; 1166 of 1754) of eligible on-campus students adhered to weekly testing; female students were more adherent (adjusted odds ratio [aOR], 2.07; 95% confidence interval, 1.66-2.59) than male students. Of all antigen test encounters, 11.5% (1409 of 12 305) reported >1 COVID-19 symptoms. Of non-COVID-19-exposed antigen test encounters, 88% (10 386 of 11 769) did not require confirmatory RT-PCR testing. Only 28% (390 of 1387) of testing encounters had an associated recommended confirmatory RT-PCR test performed. We estimated the testing strategy captured 61% (235 of 389) of predicted RT-PCR-positive specimens.
Conclusions: At this IHE, most students voluntarily adhered to serial testing. The majority of antigen test results did not require confirmatory RT-PCR testing, but when required, most students did not obtain it. Including strategies to increase the proportion of individuals obtaining indicated confirmatory testing might improve the testing program's performance.
Keywords: 19 antigen testing; 19 serial testing; 19 surveillance; 19 testing adherence; COVID; university.
. 2021 Sep 18;8(10)
fab472.doi: 10.1093/ofid/ofab472. eCollection 2021 Oct.
Application of a Serial Antigen-Based Testing Strategy for Severe Acute Respiratory Syndrome Coronavirus 2 and Student Adherence in a University Setting: Wisconsin, October-November 2020
John Paul Bigouette[SUP] 1 2 [/SUP], Laura Ford[SUP] 1 2 [/SUP], Ian Pray[SUP] 1 2 3 [/SUP], Kimberly Langolf[SUP] 4 [/SUP], Juliana Kahrs[SUP] 4 [/SUP], Tara Zochert[SUP] 4 [/SUP], Jacqueline E Tate[SUP] 1 [/SUP], Douglas Gieryn[SUP] 5 [/SUP], Hannah L Kirking[SUP] 1 [/SUP], Ryan Westergaard[SUP] 3 6 [/SUP], Marie E Killerby[SUP] 1 [/SUP]
Affiliations
- PMID: 34692890
- PMCID: PMC8530262
- DOI: 10.1093/ofid/ofab472
Abstract
Background: Serial severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing has been implemented at institutions of higher education (IHEs) and other settings. Testing strategies can include algorithms specifying confirmatory reverse-transcription polymerase chain reaction (RT-PCR) testing after an antigen test. It is unknown how testing strategies perform detecting SARS-CoV-2, including individual adherence to serial testing requirements.
Methods: Student serial testing adherence was defined as completing ≥80% of weekly tests from October 5, 2020 to November 14, 2020 and evaluated using logistic regression. Medical records were reviewed for all positive antigen test encounters and 10% of daily negative antigen test encounters during October 19-November 30, 2020. Results were used to estimate the proportion of individuals requiring only antigen tests, requiring and completing RT-PCR testing, and associated costs of tests.
Results: Two thirds (66.5%; 1166 of 1754) of eligible on-campus students adhered to weekly testing; female students were more adherent (adjusted odds ratio [aOR], 2.07; 95% confidence interval, 1.66-2.59) than male students. Of all antigen test encounters, 11.5% (1409 of 12 305) reported >1 COVID-19 symptoms. Of non-COVID-19-exposed antigen test encounters, 88% (10 386 of 11 769) did not require confirmatory RT-PCR testing. Only 28% (390 of 1387) of testing encounters had an associated recommended confirmatory RT-PCR test performed. We estimated the testing strategy captured 61% (235 of 389) of predicted RT-PCR-positive specimens.
Conclusions: At this IHE, most students voluntarily adhered to serial testing. The majority of antigen test results did not require confirmatory RT-PCR testing, but when required, most students did not obtain it. Including strategies to increase the proportion of individuals obtaining indicated confirmatory testing might improve the testing program's performance.
Keywords: 19 antigen testing; 19 serial testing; 19 surveillance; 19 testing adherence; COVID; university.