tetano
Editor, Senior Moderator
One Health
. 2025 Apr 14:20:101037.
doi: 10.1016/j.onehlt.2025.101037. eCollection 2025 Jun. How virus migration and meteorological elements shape the seasonality of influenza a/H3N2: A case study in China
Yilan Liao[SUP] 1 2 [/SUP], Tong Zhao[SUP] 1 3 [/SUP], Wei Du[SUP] 4 [/SUP], Dayan Wang[SUP] 5 [/SUP], Zhibin Peng[SUP] 6 [/SUP], Shan Xue[SUP] 1 3 [/SUP], Jianxing Yu[SUP] 7 [/SUP], An Zhang[SUP] 1 [/SUP], Hongyan Ren[SUP] 1 [/SUP], Zhoupeng Ren[SUP] 1 [/SUP], Geoge Fu Gao[SUP] 8 9 10 [/SUP], Jinfeng Wang[SUP] 1 2 [/SUP], Nils Christian Stenseth[SUP] 11 12 [/SUP]
Affiliations
Recent global influenza resurgences, escalating to pandemics, emphasize the urgency for effective vaccinations. Despite their efficacy, vaccines offer limited protection against A/H3N2 variants. Thus, elucidating the spatial patterns and underlying drivers of A/H3N2 seasonality is critical for its management. However, the mechanisms governing this seasonality are not fully understood. The study conducted a collaborative and interdisciplinary analysis of influenza A/H3N2 epidemiology in China from 2012 to 2018, utilizing national influenza surveillance data, viral gene sequence data, and meteorological information. We initially examined the spatiotemporal distribution of influenza A/H3N2 across different temperate zones in China. Subsequently, we employed Bayesian "SkyGrid" reconstruction analysis to gain insights into the population dynamics of the influenza A/H3N2 virus within China's temperature zones. Additionally, we utilized generalized additive models (GAM) to assess the influence of meteorological factors on the seasonal prevalence of influenza A/H3N2. Our analysis of China's national influenza data revealed distinct seasonal patterns for A/H3N2: winter epidemics prevailed in temperate zones, while summer and autumn outbreaks occurred in subtropical and tropical areas. The seasonality of influenza A/H3N2 across China's diverse climatic zones is shaped by the interplay of virus migration and meteorological factors. Virus migration introduced new variant populations during seasonal epidemics of influenza A/H3N2 to different temperature zones in China, thereby seeding subsequent seasonal outbreaks. Our findings also indicate that meteorological elements trigger influenza A/H3N2 activity following virus migration. Moreover, the spatial variations in influenza A/H3N2 seasonality in China can be attributed to specific temperature thresholds, approximately 1 °C and 24 °C. These thresholds could serve as potential indicators for A/H3N2 prevalence. This insight is invaluable for tailoring region-specific prevention and control strategies in China and other regions with similar environmental conditions.
Keywords: A/H3N2; Influenza seasonality; Meteorological elements; Virus migration.
. 2025 Apr 14:20:101037.
doi: 10.1016/j.onehlt.2025.101037. eCollection 2025 Jun. How virus migration and meteorological elements shape the seasonality of influenza a/H3N2: A case study in China
Yilan Liao[SUP] 1 2 [/SUP], Tong Zhao[SUP] 1 3 [/SUP], Wei Du[SUP] 4 [/SUP], Dayan Wang[SUP] 5 [/SUP], Zhibin Peng[SUP] 6 [/SUP], Shan Xue[SUP] 1 3 [/SUP], Jianxing Yu[SUP] 7 [/SUP], An Zhang[SUP] 1 [/SUP], Hongyan Ren[SUP] 1 [/SUP], Zhoupeng Ren[SUP] 1 [/SUP], Geoge Fu Gao[SUP] 8 9 10 [/SUP], Jinfeng Wang[SUP] 1 2 [/SUP], Nils Christian Stenseth[SUP] 11 12 [/SUP]
Affiliations
- PMID: 40276694
- PMCID: PMC12020868
- DOI: 10.1016/j.onehlt.2025.101037
Recent global influenza resurgences, escalating to pandemics, emphasize the urgency for effective vaccinations. Despite their efficacy, vaccines offer limited protection against A/H3N2 variants. Thus, elucidating the spatial patterns and underlying drivers of A/H3N2 seasonality is critical for its management. However, the mechanisms governing this seasonality are not fully understood. The study conducted a collaborative and interdisciplinary analysis of influenza A/H3N2 epidemiology in China from 2012 to 2018, utilizing national influenza surveillance data, viral gene sequence data, and meteorological information. We initially examined the spatiotemporal distribution of influenza A/H3N2 across different temperate zones in China. Subsequently, we employed Bayesian "SkyGrid" reconstruction analysis to gain insights into the population dynamics of the influenza A/H3N2 virus within China's temperature zones. Additionally, we utilized generalized additive models (GAM) to assess the influence of meteorological factors on the seasonal prevalence of influenza A/H3N2. Our analysis of China's national influenza data revealed distinct seasonal patterns for A/H3N2: winter epidemics prevailed in temperate zones, while summer and autumn outbreaks occurred in subtropical and tropical areas. The seasonality of influenza A/H3N2 across China's diverse climatic zones is shaped by the interplay of virus migration and meteorological factors. Virus migration introduced new variant populations during seasonal epidemics of influenza A/H3N2 to different temperature zones in China, thereby seeding subsequent seasonal outbreaks. Our findings also indicate that meteorological elements trigger influenza A/H3N2 activity following virus migration. Moreover, the spatial variations in influenza A/H3N2 seasonality in China can be attributed to specific temperature thresholds, approximately 1 °C and 24 °C. These thresholds could serve as potential indicators for A/H3N2 prevalence. This insight is invaluable for tailoring region-specific prevention and control strategies in China and other regions with similar environmental conditions.
Keywords: A/H3N2; Influenza seasonality; Meteorological elements; Virus migration.