tetano
Editor, Senior Moderator
Ocul Immunol Inflamm
. 2022 Jan 20;1-6.
doi: 10.1080/09273948.2022.2027463. Online ahead of print.
Two Cases of Acute Macular Neuroretinopathy Associated with the Adenovirus-based COVID-19 Vaccine Vaxzevria (Astrazeneca)
Alexander Franchi[SUP] 1 [/SUP], Teresa Rauchegger[SUP] 1 [/SUP], Christoph Palme[SUP] 1 [/SUP], Katharina Frede[SUP] 1 [/SUP], Gertrud Haas[SUP] 1 [/SUP], Georgios Blatsios[SUP] 1 [/SUP], Martina Kralinger[SUP] 1 [/SUP], Claus Zehetner[SUP] 1 [/SUP]
Affiliations
Abstract
Purpose: To report two cases of acute macular neuroretinopathy (AMN) in young female patients following the administration of the adenovirus-based coronavirus disease 2019 (COVID-19) vaccine Vaxzevria (AstraZeneca).
Methods: Spectral-domain optical coherence tomography and infrared imaging were used to confirm the diagnosis of AMN.
Results: Both patients showed a parafoveal hyperreflective band in the outer nuclear layer, disruption of the ellipsoid and interdigitation zones of the photoreceptor layers, and correlating hyporeflective areas on the near-infrared images. Both patients presented with flu-like fever and sudden onset of fortifications within 48 hours of vaccination. One patient showed altered flow in the deep capillary plexus and highly elevated thrombotic parameters.
Conclusion: We report a possible association between immune-mediated AMN and the administration of adenovirus-based COVID-19 vaccine Vaxzevria.
Keywords: Acute macular neuroretinopathy; COVID-19; SARS-CoV-2; vaccination; vaxzevria.
. 2022 Jan 20;1-6.
doi: 10.1080/09273948.2022.2027463. Online ahead of print.
Two Cases of Acute Macular Neuroretinopathy Associated with the Adenovirus-based COVID-19 Vaccine Vaxzevria (Astrazeneca)
Alexander Franchi[SUP] 1 [/SUP], Teresa Rauchegger[SUP] 1 [/SUP], Christoph Palme[SUP] 1 [/SUP], Katharina Frede[SUP] 1 [/SUP], Gertrud Haas[SUP] 1 [/SUP], Georgios Blatsios[SUP] 1 [/SUP], Martina Kralinger[SUP] 1 [/SUP], Claus Zehetner[SUP] 1 [/SUP]
Affiliations
- PMID: 35050829
- DOI: 10.1080/09273948.2022.2027463
Abstract
Purpose: To report two cases of acute macular neuroretinopathy (AMN) in young female patients following the administration of the adenovirus-based coronavirus disease 2019 (COVID-19) vaccine Vaxzevria (AstraZeneca).
Methods: Spectral-domain optical coherence tomography and infrared imaging were used to confirm the diagnosis of AMN.
Results: Both patients showed a parafoveal hyperreflective band in the outer nuclear layer, disruption of the ellipsoid and interdigitation zones of the photoreceptor layers, and correlating hyporeflective areas on the near-infrared images. Both patients presented with flu-like fever and sudden onset of fortifications within 48 hours of vaccination. One patient showed altered flow in the deep capillary plexus and highly elevated thrombotic parameters.
Conclusion: We report a possible association between immune-mediated AMN and the administration of adenovirus-based COVID-19 vaccine Vaxzevria.
Keywords: Acute macular neuroretinopathy; COVID-19; SARS-CoV-2; vaccination; vaxzevria.