tetano
Editor, Senior Moderator
Eur J Pediatr. 2017 Jan 21. doi: 10.1007/s00431-017-2856-5. [Epub ahead of print]
[h=1]Occurrence of atypical HUS associated with influenza B.[/h] van Hoeve K[SUP]1[/SUP], Vandermeulen C[SUP]2[/SUP], Van Ranst M[SUP]3[/SUP], Levtchenko E[SUP]4,[/SUP][SUP]5[/SUP], van den Heuvel L[SUP]5[/SUP], Mekahli D[SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Hemolytic uremic syndrome (HUS) is a disease characterized by thrombotic microangiopathy with a triad of non-immune hemolytic anemia, thrombocytopenia, and renal impairment. Approximately 10% of cases of HUS are classified as atypical (aHUS). While today many genetically forms of aHUS pathology are known, only about 50% of carriers precipitate the disease. The reason remains unclear, and triggering events like intercurrent infections have been postulated. In rare cases, influenza A is the known trigger of aHUS; however, no cases of influenza B have been reported.
[h=4]CONCLUSION:[/h] We describe for the first time that influenza B strain as a trigger for aHUS in children with primary hereditary forms. We also showed in our three cases that immunization appears to be safe; however, this needs to be confirmed in a larger cohort. What is Known: ? Known triggers of aHUS are infectious specimen. ? Influenza A-associated aHUS cases are rarely published. What is New: ? aHUS can be triggered by influenza B virus infection. ? Influenza vaccination of patients with aHUS appears safe.
[h=4]KEYWORDS:[/h] Atypical hemolytic uremic syndrome; Hemolytic uremic syndrome; Influenza B; Vaccination
PMID: 28110418 DOI: 10.1007/s00431-017-2856-5
[PubMed - as supplied by publisher]
[h=1]Occurrence of atypical HUS associated with influenza B.[/h] van Hoeve K[SUP]1[/SUP], Vandermeulen C[SUP]2[/SUP], Van Ranst M[SUP]3[/SUP], Levtchenko E[SUP]4,[/SUP][SUP]5[/SUP], van den Heuvel L[SUP]5[/SUP], Mekahli D[SUP]4,[/SUP][SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Hemolytic uremic syndrome (HUS) is a disease characterized by thrombotic microangiopathy with a triad of non-immune hemolytic anemia, thrombocytopenia, and renal impairment. Approximately 10% of cases of HUS are classified as atypical (aHUS). While today many genetically forms of aHUS pathology are known, only about 50% of carriers precipitate the disease. The reason remains unclear, and triggering events like intercurrent infections have been postulated. In rare cases, influenza A is the known trigger of aHUS; however, no cases of influenza B have been reported.
[h=4]CONCLUSION:[/h] We describe for the first time that influenza B strain as a trigger for aHUS in children with primary hereditary forms. We also showed in our three cases that immunization appears to be safe; however, this needs to be confirmed in a larger cohort. What is Known: ? Known triggers of aHUS are infectious specimen. ? Influenza A-associated aHUS cases are rarely published. What is New: ? aHUS can be triggered by influenza B virus infection. ? Influenza vaccination of patients with aHUS appears safe.
[h=4]KEYWORDS:[/h] Atypical hemolytic uremic syndrome; Hemolytic uremic syndrome; Influenza B; Vaccination
PMID: 28110418 DOI: 10.1007/s00431-017-2856-5
[PubMed - as supplied by publisher]