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Editor, Senior Moderator
International Journal of Gynecology & Obstetrics
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doi:10.1016/j.ijgo.2011.10.026 | How to Cite or Link Using DOI
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Clinical article
Obstetric, clinical, and perinatal implications of H1N1 viral infection during pregnancy
Ernesto A. Figueir?-Filhoa, Corresponding Author Contact Information, E-mail The Corresponding Author, Myrna L.G. Oliveirab, Maur?cio A. Pompilioc, Silvia N.O. Ueharad, L?lian R. Coelhoe, Bruno A. De Souzae, Ili Bredae
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a Department of Gynecology and Obstetrics, School of Medicine?Federal University of Mato Grosso do Sul (FAMED?UFMS), Campo Grande, Brazil
b Post-Graduation Program in Health and Development of Midwestern Region, FAMED?UFMS, Campo Grande, Brazil
c Department of Internal Medicine, FAMED?UFMS, Campo Grande, Brazil
d Infectious and Parasitic Diseases Division, University Hospital, FAMED?UFMS, Campo Grande, Brazil
e FAMED?UFMS, Campo Grande, Brazil
Received 20 July 2011; revised 7 October 2011; Accepted 24 November 2011. Available online 22 December 2011.
Abstract
Objective
To determine perinatal outcome and epidemiologic, clinical, and obstetric characteristics among pregnant women infected with the H1N1 virus admitted to a Brazilian university hospital.
Methods
A cross-sectional study was conducted of pregnant women infected with H1N1 who were admitted to the University Hospital at the School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Brazil, during the 2009 pandemic. Data were obtained via a questionnaire, which was administered during the hospital evaluation of patients? medical records.
Results
Thirty-one patients were included in the study. Antiviral therapy was initiated within 48 hours of the onset of symptoms in 64.5% of cases. Infection with the H1N1 virus was associated with severe clinical complications in 22.6% of patients and adverse perinatal outcomes in 41.9% of cases. The rate of maternal and perinatal mortality was 9.7%. There was a statistically significant association between late treatment with oseltamivir and increase in systemic complications in pregnancy (odds ratio 22.80 [95% confidence interval, 2.20?235.65]; P = 0.007).
Conclusion
Early treatment with oseltamivir may prevent serious complications associated with H1N1 infection in pregnant women but it does not affect perinatal outcome.
http://www.sciencedirect.com/science/article/pii/S0020729211006047
In Press, Corrected Proof - Note to users
doi:10.1016/j.ijgo.2011.10.026 | How to Cite or Link Using DOI
Permissions & Reprints
Clinical article
Obstetric, clinical, and perinatal implications of H1N1 viral infection during pregnancy
Ernesto A. Figueir?-Filhoa, Corresponding Author Contact Information, E-mail The Corresponding Author, Myrna L.G. Oliveirab, Maur?cio A. Pompilioc, Silvia N.O. Ueharad, L?lian R. Coelhoe, Bruno A. De Souzae, Ili Bredae
Purchase
a Department of Gynecology and Obstetrics, School of Medicine?Federal University of Mato Grosso do Sul (FAMED?UFMS), Campo Grande, Brazil
b Post-Graduation Program in Health and Development of Midwestern Region, FAMED?UFMS, Campo Grande, Brazil
c Department of Internal Medicine, FAMED?UFMS, Campo Grande, Brazil
d Infectious and Parasitic Diseases Division, University Hospital, FAMED?UFMS, Campo Grande, Brazil
e FAMED?UFMS, Campo Grande, Brazil
Received 20 July 2011; revised 7 October 2011; Accepted 24 November 2011. Available online 22 December 2011.
Abstract
Objective
To determine perinatal outcome and epidemiologic, clinical, and obstetric characteristics among pregnant women infected with the H1N1 virus admitted to a Brazilian university hospital.
Methods
A cross-sectional study was conducted of pregnant women infected with H1N1 who were admitted to the University Hospital at the School of Medicine, Federal University of Mato Grosso do Sul, Campo Grande, Brazil, during the 2009 pandemic. Data were obtained via a questionnaire, which was administered during the hospital evaluation of patients? medical records.
Results
Thirty-one patients were included in the study. Antiviral therapy was initiated within 48 hours of the onset of symptoms in 64.5% of cases. Infection with the H1N1 virus was associated with severe clinical complications in 22.6% of patients and adverse perinatal outcomes in 41.9% of cases. The rate of maternal and perinatal mortality was 9.7%. There was a statistically significant association between late treatment with oseltamivir and increase in systemic complications in pregnancy (odds ratio 22.80 [95% confidence interval, 2.20?235.65]; P = 0.007).
Conclusion
Early treatment with oseltamivir may prevent serious complications associated with H1N1 infection in pregnant women but it does not affect perinatal outcome.
http://www.sciencedirect.com/science/article/pii/S0020729211006047