tetano
Editor, Senior Moderator
Obstet Gynecol Sci
. 2023 Jan 4.
doi: 10.5468/ogs.22175. Online ahead of print.
The complement system in preeclampsia: a review of its activation and endothelial injury in the triad of COVID 19 infection and HIV-associated preeclampsia
Mikyle David[SUP] 1 [/SUP], Thajasvarie Naicker[SUP] 1 [/SUP]
Affiliations
Abstract
This review assessed the complement system and its activation with respect to the pathological features of severe acute respiratory syndrome (SARS-CoV-2), human immunodeficiency virus (HIV) infection, and preeclampsia (PE). The complement system is the first defensive response of the host innate immune system to viral pathogens, including SARS-Cov-2. SARS-CoV-2 entry results in the release of proinflammatory cytokines and chemical mediators to create a "cytokine storm". Endothelial cell (EC) dysfunction and cell-mediated injury are also observed. These factors exacerbate inflammation. During HIV infection and PE, various complement components are elevated, causing a hyperinflammatory state. Furthermore, EC dysfunction and cell-mediated injury are also observed. The similarities in the pathological aspects of these three disorders may emanate from excessive complement activation. This review serves as a platform for further research on the complement system, coronavirus disease-2019, HIV, and PE.
Keywords: Complement system; HIV infection; Preeclampsia; SARS-CoV-2.
. 2023 Jan 4.
doi: 10.5468/ogs.22175. Online ahead of print.
The complement system in preeclampsia: a review of its activation and endothelial injury in the triad of COVID 19 infection and HIV-associated preeclampsia
Mikyle David[SUP] 1 [/SUP], Thajasvarie Naicker[SUP] 1 [/SUP]
Affiliations
- PMID: 36597584
- DOI: 10.5468/ogs.22175
Abstract
This review assessed the complement system and its activation with respect to the pathological features of severe acute respiratory syndrome (SARS-CoV-2), human immunodeficiency virus (HIV) infection, and preeclampsia (PE). The complement system is the first defensive response of the host innate immune system to viral pathogens, including SARS-Cov-2. SARS-CoV-2 entry results in the release of proinflammatory cytokines and chemical mediators to create a "cytokine storm". Endothelial cell (EC) dysfunction and cell-mediated injury are also observed. These factors exacerbate inflammation. During HIV infection and PE, various complement components are elevated, causing a hyperinflammatory state. Furthermore, EC dysfunction and cell-mediated injury are also observed. The similarities in the pathological aspects of these three disorders may emanate from excessive complement activation. This review serves as a platform for further research on the complement system, coronavirus disease-2019, HIV, and PE.
Keywords: Complement system; HIV infection; Preeclampsia; SARS-CoV-2.