tetano
Editor, Senior Moderator
Obstet Gynecol Sci
. 2022 Aug 2.
doi: 10.5468/ogs.22060. Online ahead of print.
COVID-19 and vaccination during pregnancy: a systematic analysis using Korea National Health Insurance claims data
Ki Hoon Ahn[SUP] 1 [/SUP], Hae-In Kim[SUP] 1 2 3 [/SUP], Kwang-Sig Lee[SUP] 3 [/SUP], Ju Sun Heo[SUP] 4 [/SUP], Ho-Yeon Kim[SUP] 1 [/SUP], Geum-Joon Cho[SUP] 1 [/SUP], Soon-Cheol Hong[SUP] 1 [/SUP], Min-Jeong Oh[SUP] 1 [/SUP], Hae-Joong Kim[SUP] 1 [/SUP]
Affiliations
Abstract
Objective: This study systematically analyzed coronavirus disease 2019 (COVID-19) and vaccination details during pregnancy by using the national health insurance claims data.
Methods: Population-based retrospective cohort data of 12,399,065 women aged 15-49 years were obtained from the Korea National Health Insurance Service claims database between 2019 and 2021. Univariate analysis was performed to compare the obstetric outcomes of pregnant women (ICD-10 O00-O94) and their newborns (ICD-10 P00-P96) with and without COVID-19. Univariate analysis was also performed to compare the age and obstetric outcomes of pregnant women receiving different types of vaccines.
Results: The percentage of pregnant women with COVID-19 during pregnancy was 0.11%. Some obstetric outcomes of pregnant women with COVID-19, including the rates of preterm birth or cesarean delivery, were significantly better than those of pregnant women without COVID-19. The rate of miscarriage was higher in pregnant women with COVID-19 than without COVID-19. However, the outcomes of newborns of women with and without COVID-19 were not significantly different. Regarding vaccination type, obstetric outcomes of pregnant women appeared to be worse with the viral vector vaccine than with the mRNA vaccine.
Conclusion: To the best of our knowledge, this is the first study to systematically analyze COVID-19 and vaccination details during pregnancy using the national health insurance claims data in Korea. The obstetric outcomes in pregnant women with and without COVID-19 and their newborns were similar.
Keywords: COVID-19; Infant, newborn; Pregnancy; Pregnancy outcome; Vaccination.
. 2022 Aug 2.
doi: 10.5468/ogs.22060. Online ahead of print.
COVID-19 and vaccination during pregnancy: a systematic analysis using Korea National Health Insurance claims data
Ki Hoon Ahn[SUP] 1 [/SUP], Hae-In Kim[SUP] 1 2 3 [/SUP], Kwang-Sig Lee[SUP] 3 [/SUP], Ju Sun Heo[SUP] 4 [/SUP], Ho-Yeon Kim[SUP] 1 [/SUP], Geum-Joon Cho[SUP] 1 [/SUP], Soon-Cheol Hong[SUP] 1 [/SUP], Min-Jeong Oh[SUP] 1 [/SUP], Hae-Joong Kim[SUP] 1 [/SUP]
Affiliations
- PMID: 35916014
- DOI: 10.5468/ogs.22060
Abstract
Objective: This study systematically analyzed coronavirus disease 2019 (COVID-19) and vaccination details during pregnancy by using the national health insurance claims data.
Methods: Population-based retrospective cohort data of 12,399,065 women aged 15-49 years were obtained from the Korea National Health Insurance Service claims database between 2019 and 2021. Univariate analysis was performed to compare the obstetric outcomes of pregnant women (ICD-10 O00-O94) and their newborns (ICD-10 P00-P96) with and without COVID-19. Univariate analysis was also performed to compare the age and obstetric outcomes of pregnant women receiving different types of vaccines.
Results: The percentage of pregnant women with COVID-19 during pregnancy was 0.11%. Some obstetric outcomes of pregnant women with COVID-19, including the rates of preterm birth or cesarean delivery, were significantly better than those of pregnant women without COVID-19. The rate of miscarriage was higher in pregnant women with COVID-19 than without COVID-19. However, the outcomes of newborns of women with and without COVID-19 were not significantly different. Regarding vaccination type, obstetric outcomes of pregnant women appeared to be worse with the viral vector vaccine than with the mRNA vaccine.
Conclusion: To the best of our knowledge, this is the first study to systematically analyze COVID-19 and vaccination details during pregnancy using the national health insurance claims data in Korea. The obstetric outcomes in pregnant women with and without COVID-19 and their newborns were similar.
Keywords: COVID-19; Infant, newborn; Pregnancy; Pregnancy outcome; Vaccination.