tetano
Editor, Senior Moderator
Influenza Other Respi Viruses. 2013 Aug 20. doi: 10.1111/irv.12156. [Epub ahead of print]
Obesity as a risk factor for severe influenza-like illness.
Cocoros NM, Lash TL, Demaria A Jr, Klompas M.
Source
Bureau of Infectious Disease, Massachusetts Department of Public Health, Jamaica Plain, MA, USA.
Abstract
BACKGROUND:
Obesity was recognized as in independent risk factor for influenza during the 2009 H1N1 influenza pandemic.
OBJECTIVES:
We evaluated the association between body mass index (BMI) and influenza-like illness (ILI) during two non-pandemic influenza seasons (2003-2004 and 2004-2005) and during the spring and fall waves of the 2009 H1N1 pandemic.
METHODS:
Adults with severe (inpatient) and mild (outpatient) ILI were compared to those without ILI using a case-cohort design. The study was nested among those insured by a single health insurance company, receiving care from a large multispecialty practice. Data were collected from insurance claims and the electronic health record. The primary exposure was obesity (BMI ≥ 30?0 kg/m2 ).
RESULTS:
Across three seasons, the crude and adjusted ORs for obesity and severe ILI were 1?65 (95% CI 1?31, 2?08) and 1?23 (95% CI 0?97, 1?57), respectively. An association was observed for those aged 20-59 years (adjusted OR 1?92, 95% CI 1?26, 2?90), but not for those 60 and older (adjusted OR 1?08, 95% CI 0?80, 1?46). The adjusted ORs for obesity and severe ILI in 2003-2004, 2004-2005, and during H1N1 were 1?14 (95% CI 0?80, 1?64), 1?24 (95% CI 0?86, 1?79), and 1?76 (95% CI 0?91, 3?42), respectively. Among those with a Charlson Comorbidity Index score of zero, the adjusted ORs for 2003-2004, 2004-2005, and H1N1 were 1?60 (95% CI 0?93, 2?76), 1?43 (95% CI 0?80, 2?56), and 1?90 (95% CI 0?68, 5?27), respectively.
CONCLUSIONS:
Our results suggest a small to moderate association between obesity and hospitalized ILI among adults.
? 2013 John Wiley & Sons Ltd.
KEYWORDS:
BMI , influenza, obesity
PMID:
23957732
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23957732
Obesity as a risk factor for severe influenza-like illness.
Cocoros NM, Lash TL, Demaria A Jr, Klompas M.
Source
Bureau of Infectious Disease, Massachusetts Department of Public Health, Jamaica Plain, MA, USA.
Abstract
BACKGROUND:
Obesity was recognized as in independent risk factor for influenza during the 2009 H1N1 influenza pandemic.
OBJECTIVES:
We evaluated the association between body mass index (BMI) and influenza-like illness (ILI) during two non-pandemic influenza seasons (2003-2004 and 2004-2005) and during the spring and fall waves of the 2009 H1N1 pandemic.
METHODS:
Adults with severe (inpatient) and mild (outpatient) ILI were compared to those without ILI using a case-cohort design. The study was nested among those insured by a single health insurance company, receiving care from a large multispecialty practice. Data were collected from insurance claims and the electronic health record. The primary exposure was obesity (BMI ≥ 30?0 kg/m2 ).
RESULTS:
Across three seasons, the crude and adjusted ORs for obesity and severe ILI were 1?65 (95% CI 1?31, 2?08) and 1?23 (95% CI 0?97, 1?57), respectively. An association was observed for those aged 20-59 years (adjusted OR 1?92, 95% CI 1?26, 2?90), but not for those 60 and older (adjusted OR 1?08, 95% CI 0?80, 1?46). The adjusted ORs for obesity and severe ILI in 2003-2004, 2004-2005, and during H1N1 were 1?14 (95% CI 0?80, 1?64), 1?24 (95% CI 0?86, 1?79), and 1?76 (95% CI 0?91, 3?42), respectively. Among those with a Charlson Comorbidity Index score of zero, the adjusted ORs for 2003-2004, 2004-2005, and H1N1 were 1?60 (95% CI 0?93, 2?76), 1?43 (95% CI 0?80, 2?56), and 1?90 (95% CI 0?68, 5?27), respectively.
CONCLUSIONS:
Our results suggest a small to moderate association between obesity and hospitalized ILI among adults.
? 2013 John Wiley & Sons Ltd.
KEYWORDS:
BMI , influenza, obesity
PMID:
23957732
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23957732