tetano
Editor, Senior Moderator
Thorax. 2013 Feb 22. doi: 10.1136/thoraxjnl-2012-203009. [Epub ahead of print]
Obesity and susceptibility to severe outcomes following respiratory viral infection.
Almond MH, Edwards MR, Barclay WS, Johnston SL.
Source
Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, UK.
Abstract
During the 2009 H1N1 influenza pandemic, obesity was convincingly identified as a novel, independent risk factor for multiple markers of disease severity. Associations between numerous nosocomial and community-acquired clinical infections have previously been established; yet, little is known about the mechanisms underpinning the increased susceptibility to severe outcomes following pandemic H1N1/09 infection in obesity. Here, we present a brief synthesis of the recent advances in our understanding of the immunomodulatory effects of obesity on outcomes following respiratory viral infection, with a particular focus on pandemic influenza.
PMID:
23436045
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23436045
Obesity and susceptibility to severe outcomes following respiratory viral infection.
Almond MH, Edwards MR, Barclay WS, Johnston SL.
Source
Airway Disease Infection Section, National Heart and Lung Institute, Imperial College London, UK.
Abstract
During the 2009 H1N1 influenza pandemic, obesity was convincingly identified as a novel, independent risk factor for multiple markers of disease severity. Associations between numerous nosocomial and community-acquired clinical infections have previously been established; yet, little is known about the mechanisms underpinning the increased susceptibility to severe outcomes following pandemic H1N1/09 infection in obesity. Here, we present a brief synthesis of the recent advances in our understanding of the immunomodulatory effects of obesity on outcomes following respiratory viral infection, with a particular focus on pandemic influenza.
PMID:
23436045
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23436045