tetano
Editor, Senior Moderator
Nutrients. 2020 May 9;12(5). pii: E1359. doi: 10.3390/nu12051359.
25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2.
D'Avolio A[SUP]1[/SUP], Avataneo V[SUP]1[/SUP], Manca A[SUP]1[/SUP], Cusato J[SUP]1[/SUP], De Nicol? A[SUP]1[/SUP], Lucchini R[SUP]2[/SUP], Keller F[SUP]2[/SUP], Cant? M[SUP]2[/SUP].
Author information
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), with a clinical outcome ranging from mild to severe, including death. To date, it is unclear why some patients develop severe symptoms. Many authors have suggested the involvement of vitamin D in reducing the risk of infections; thus, we retrospectively investigated the 25-hydroxyvitamin D (25(OH)D) concentrations in plasma obtained from a cohort of patients from Switzerland. In this cohort, significantly lower 25(OH)D levels (p = 0.004) were found in PCR-positive for SARS-CoV-2 (median value 11.1 ng/mL) patients compared with negative patients (24.6 ng/mL); this was also confirmed by stratifying patients according to age >70 years. On the basis of this preliminary observation, vitamin D supplementation might be a useful measure to reduce the risk of infection. Randomized controlled trials and large population studies should be conducted to evaluate these recommendations and to confirm our preliminary observation.
KEYWORDS:
COVID-19; SARS-CoV-2; concentrations; coronavirus; deficiency; vitamin D
PMID:32397511DOI:10.3390/nu12051359
[Indexed for MEDLINE]Free full text
25-Hydroxyvitamin D Concentrations Are Lower in Patients with Positive PCR for SARS-CoV-2.
D'Avolio A[SUP]1[/SUP], Avataneo V[SUP]1[/SUP], Manca A[SUP]1[/SUP], Cusato J[SUP]1[/SUP], De Nicol? A[SUP]1[/SUP], Lucchini R[SUP]2[/SUP], Keller F[SUP]2[/SUP], Cant? M[SUP]2[/SUP].
Author information
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), with a clinical outcome ranging from mild to severe, including death. To date, it is unclear why some patients develop severe symptoms. Many authors have suggested the involvement of vitamin D in reducing the risk of infections; thus, we retrospectively investigated the 25-hydroxyvitamin D (25(OH)D) concentrations in plasma obtained from a cohort of patients from Switzerland. In this cohort, significantly lower 25(OH)D levels (p = 0.004) were found in PCR-positive for SARS-CoV-2 (median value 11.1 ng/mL) patients compared with negative patients (24.6 ng/mL); this was also confirmed by stratifying patients according to age >70 years. On the basis of this preliminary observation, vitamin D supplementation might be a useful measure to reduce the risk of infection. Randomized controlled trials and large population studies should be conducted to evaluate these recommendations and to confirm our preliminary observation.
KEYWORDS:
COVID-19; SARS-CoV-2; concentrations; coronavirus; deficiency; vitamin D
PMID:32397511DOI:10.3390/nu12051359
[Indexed for MEDLINE]Free full text