tetano
Editor, Senior Moderator
Vaccine. 2012 May 29. [Epub ahead of print]
Nuclear import of the influenza A virus transcriptional machinery.
Hutchinson EC, Fodor E.
Source
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom.
Abstract
Unusually for an RNA virus, influenza A viruses transcribe and replicate their genomes in the nuclei of infected cells. As a result the viral ribonucleoprotein complexes (RNPs), and their newly synthesised protein subunits, must interact with the host nuclear import machinery. In this review we discuss how the virus exploits nuclear import pathways to allow regulated and chaperoned assembly of RNPs in the nucleus, and describe how the import machinery itself can be a determinant of host tropism.
Copyright ? 2012. Published by Elsevier Ltd.
PMID:
22652398
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22652398
Nuclear import of the influenza A virus transcriptional machinery.
Hutchinson EC, Fodor E.
Source
Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom.
Abstract
Unusually for an RNA virus, influenza A viruses transcribe and replicate their genomes in the nuclei of infected cells. As a result the viral ribonucleoprotein complexes (RNPs), and their newly synthesised protein subunits, must interact with the host nuclear import machinery. In this review we discuss how the virus exploits nuclear import pathways to allow regulated and chaperoned assembly of RNPs in the nucleus, and describe how the import machinery itself can be a determinant of host tropism.
Copyright ? 2012. Published by Elsevier Ltd.
PMID:
22652398
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22652398