tetano
Editor, Senior Moderator
Dokl Biochem Biophys. 2019 May;486(1):201-205. doi: 10.1134/S1607672919030128. Epub 2019 Jul 31.
[h=1]NSP Protein Encoded in Negative NS RNA Strand of Influenza A Virus Induces Cellular Immune Response in Infected Animals.[/h] Zhirnov OP[SUP]1,[/SUP][SUP]2[/SUP], Isaeva EI[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Infection of mice with influenza A viruses led to the formation of clones of lymphocytes that specifically recognizes viral domains in the central zone of the NSP protein (amino acid positions 83-119). Computer analysis of the primary structure of the NSP protein showed the presence of T-cell epitopes in the central part of the NSP molecule. The findings indicate that the viral NSP gene is expressed in the infected animals and verify the concept of the bipolar strategy (ambisense strategy) of the influenza A virus genome.
PMID: 31367821 DOI: 10.1134/S1607672919030128
[h=1]NSP Protein Encoded in Negative NS RNA Strand of Influenza A Virus Induces Cellular Immune Response in Infected Animals.[/h] Zhirnov OP[SUP]1,[/SUP][SUP]2[/SUP], Isaeva EI[SUP]3[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Infection of mice with influenza A viruses led to the formation of clones of lymphocytes that specifically recognizes viral domains in the central zone of the NSP protein (amino acid positions 83-119). Computer analysis of the primary structure of the NSP protein showed the presence of T-cell epitopes in the central part of the NSP molecule. The findings indicate that the viral NSP gene is expressed in the infected animals and verify the concept of the bipolar strategy (ambisense strategy) of the influenza A virus genome.
PMID: 31367821 DOI: 10.1134/S1607672919030128