tetano
Editor, Senior Moderator
Npj Viruses
. 2024 Nov 21;2(1):58.
doi: 10.1038/s44298-024-00067-9. Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses
Tyler M Renner[SUP] 1 [/SUP], Matthew Stuible[SUP] 2 [/SUP], Brian Cass[SUP] 2 [/SUP], Sylvie Perret[SUP] 2 [/SUP], Julie Guimond[SUP] 2 [/SUP], Simon Lord-Dufour[SUP] 2 [/SUP], Michael J McCluskie[SUP] 1 [/SUP], Yves Durocher[SUP] 3 [/SUP], Bassel Akache[SUP] 4 [/SUP]
Affiliations
The COVID-19 pandemic has emphasised the importance of vaccines and preparedness against viral threats crossing species barriers. In response, a worldwide vaccination campaign targeting SARS-CoV-2 was implemented, which provides some cross-protective immunological memory to other coronavirus species with zoonotic potential. Following a vaccination regimen against SARS-CoV-2 spike in a preclinical mouse model, we were able to demonstrate the induction of neutralizing antibodies towards multiple human ACE2 (hACE2)-binding Sarbecovirus spikes. Importantly, compared to vaccines based on the SARS-CoV-2 Reference strain, vaccines based on Omicron spike sequences induced drastically less broadly cross-protective neutralizing antibodies against other hACE2-binding sarbecoviruses. This observation remained true whether the vaccination regimens were based on protein subunit or mRNA / LNP vaccines. Overall, while it may be necessary to update vaccine antigens to combat the evolving SARS-CoV-2 virus for enhanced protection from COVID-19, Reference-based vaccines may be a more valuable tool to protect against novel coronavirus zoonoses.
. 2024 Nov 21;2(1):58.
doi: 10.1038/s44298-024-00067-9. Reduced cross-protective potential of Omicron compared to ancestral SARS-CoV-2 spike vaccines against potentially zoonotic coronaviruses
Tyler M Renner[SUP] 1 [/SUP], Matthew Stuible[SUP] 2 [/SUP], Brian Cass[SUP] 2 [/SUP], Sylvie Perret[SUP] 2 [/SUP], Julie Guimond[SUP] 2 [/SUP], Simon Lord-Dufour[SUP] 2 [/SUP], Michael J McCluskie[SUP] 1 [/SUP], Yves Durocher[SUP] 3 [/SUP], Bassel Akache[SUP] 4 [/SUP]
Affiliations
- PMID: 40295830
- DOI: 10.1038/s44298-024-00067-9
The COVID-19 pandemic has emphasised the importance of vaccines and preparedness against viral threats crossing species barriers. In response, a worldwide vaccination campaign targeting SARS-CoV-2 was implemented, which provides some cross-protective immunological memory to other coronavirus species with zoonotic potential. Following a vaccination regimen against SARS-CoV-2 spike in a preclinical mouse model, we were able to demonstrate the induction of neutralizing antibodies towards multiple human ACE2 (hACE2)-binding Sarbecovirus spikes. Importantly, compared to vaccines based on the SARS-CoV-2 Reference strain, vaccines based on Omicron spike sequences induced drastically less broadly cross-protective neutralizing antibodies against other hACE2-binding sarbecoviruses. This observation remained true whether the vaccination regimens were based on protein subunit or mRNA / LNP vaccines. Overall, while it may be necessary to update vaccine antigens to combat the evolving SARS-CoV-2 virus for enhanced protection from COVID-19, Reference-based vaccines may be a more valuable tool to protect against novel coronavirus zoonoses.