tetano
Editor, Senior Moderator
NPJ Vaccines
. 2022 Jun 24;7(1):67.
doi: 10.1038/s41541-022-00490-0.
Seasonal influenza vaccination expands hemagglutinin-specific antibody breadth to older and future A/H3N2 viruses
Nina Urke Ertesvåg[SUP] 1 [/SUP], Rebecca Jane Cox[SUP] 2 3 [/SUP], Sarah Larteley Lartey[SUP] 2 [/SUP], Kristin G-I Mohn[SUP] 2 4 [/SUP], Karl Albert Brokstad[SUP] 2 [/SUP], Mai-Chi Trieu[SUP] 5 [/SUP]
Affiliations
Abstract
History of influenza A/H3N2 exposure, especially childhood infection, shape antibody responses after influenza vaccination and infection, but have not been extensively studied. We investigated the breadth and durability of influenza A/H3N2-specific hemagglutinin-inhibition antibodies after live-attenuated influenza vaccine in children (aged 3-17 years, n = 42), and after inactivated influenza vaccine or infection in adults (aged 22-61 years, n = 42) using 14 antigenically distinct A/H3N2 viruses circulating from 1968 to 2018. We found that vaccination and infection elicited cross-reactive antibody responses, predominantly directed against newer or future strains. Childhood H3-priming increased the breadth and magnitude of back-boosted A/H3N2-specific antibodies in adults. Broader and more durable A/H3N2-specific antibodies were observed in repeatedly vaccinated adults than in children and previously unvaccinated adults. Our findings suggest that early A/H3N2 exposure and frequent seasonal vaccination could increase the breadth and seropositivity of antibody responses, which may improve vaccine protection against future viruses.
. 2022 Jun 24;7(1):67.
doi: 10.1038/s41541-022-00490-0.
Seasonal influenza vaccination expands hemagglutinin-specific antibody breadth to older and future A/H3N2 viruses
Nina Urke Ertesvåg[SUP] 1 [/SUP], Rebecca Jane Cox[SUP] 2 3 [/SUP], Sarah Larteley Lartey[SUP] 2 [/SUP], Kristin G-I Mohn[SUP] 2 4 [/SUP], Karl Albert Brokstad[SUP] 2 [/SUP], Mai-Chi Trieu[SUP] 5 [/SUP]
Affiliations
- PMID: 35750781
- PMCID: PMC9232600
- DOI: 10.1038/s41541-022-00490-0
Abstract
History of influenza A/H3N2 exposure, especially childhood infection, shape antibody responses after influenza vaccination and infection, but have not been extensively studied. We investigated the breadth and durability of influenza A/H3N2-specific hemagglutinin-inhibition antibodies after live-attenuated influenza vaccine in children (aged 3-17 years, n = 42), and after inactivated influenza vaccine or infection in adults (aged 22-61 years, n = 42) using 14 antigenically distinct A/H3N2 viruses circulating from 1968 to 2018. We found that vaccination and infection elicited cross-reactive antibody responses, predominantly directed against newer or future strains. Childhood H3-priming increased the breadth and magnitude of back-boosted A/H3N2-specific antibodies in adults. Broader and more durable A/H3N2-specific antibodies were observed in repeatedly vaccinated adults than in children and previously unvaccinated adults. Our findings suggest that early A/H3N2 exposure and frequent seasonal vaccination could increase the breadth and seropositivity of antibody responses, which may improve vaccine protection against future viruses.