tetano
Editor, Senior Moderator
NPJ Vaccines
. 2023 Jul 15;8(1):103.
doi: 10.1038/s41541-023-00698-8. Maternal and neonatal outcomes of COVID-19 vaccination during pregnancy, a systematic review and meta-analysis
Greg Marchand[SUP] 1 [/SUP], Ahmed Taher Masoud[SUP] 2 3 [/SUP], Sandeep Grover[SUP] 4 [/SUP], Alexa King[SUP] 2 [/SUP], Giovanna Brazil[SUP] 2 [/SUP], Hollie Ulibarri[SUP] 2 [/SUP], Julia Parise[SUP] 2 [/SUP], Amanda Arroyo[SUP] 2 [/SUP], Catherine Coriell[SUP] 2 [/SUP], Sydnee Goetz[SUP] 2 [/SUP], Carmen Moir[SUP] 2 [/SUP], Malini Govindan[SUP] 2 [/SUP], Atley Moberly[SUP] 2 [/SUP], Anna Proctor[SUP] 5 [/SUP], Katelyn Sainz[SUP] 6 [/SUP], Richard Blumrick[SUP] 7 [/SUP]
Affiliations
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is associated with increased pregnancy complications. Despite effective vaccination strategies for the general population, the evidence on the safety and efficacy of Coronavirus disease 2019 (COVID-19) vaccinations in pregnancy is limited due to a lack of well-powered studies. The present study compares the maternal, neonatal, and immunological outcomes between vaccinated pregnant and unvaccinated pregnant women using a systematic review and meta-analysis approach. We included 37 studies with a total of 141,107 pregnant women (36.8% vaccinated) spread across all outcomes. Our evidence indicates a higher rate of cesarean section in the 1898 vaccinated pregnant women compared to the 6180 women who did not receive vaccination (OR = 1.20, CI = (1.05, 1.38), P = 0.007, I2 = 45%). Regarding immunological outcomes, the risk of SARS-CoV-2 infection during pregnancy or postpartum was significantly reduced in 6820 vaccinated pregnant women compared to 17,010 unvaccinated pregnant women (OR = 0.25, CI = 0.13-0.48, P < 0.0001, I[SUP]2[/SUP] = 61%), as evident from qualitative assessment indicating significantly higher postpartum antibody titers compared to that observed in both unvaccinated mothers and mothers who have recently recovered from a SARS-CoV-2 infection. Our analysis represents high quality evidence showing that COVID-19 vaccination effectively raises antibody titers against SARS-CoV-2. This may confer protection against infection during pregnancy and the postpartum period. In addition to being protective against SARS-CoV-2, the vaccine was associated with decreased odds of preterm delivery. Furthermore, COVID-19 vaccination may also be associated with higher odds of cesarean section.
. 2023 Jul 15;8(1):103.
doi: 10.1038/s41541-023-00698-8. Maternal and neonatal outcomes of COVID-19 vaccination during pregnancy, a systematic review and meta-analysis
Greg Marchand[SUP] 1 [/SUP], Ahmed Taher Masoud[SUP] 2 3 [/SUP], Sandeep Grover[SUP] 4 [/SUP], Alexa King[SUP] 2 [/SUP], Giovanna Brazil[SUP] 2 [/SUP], Hollie Ulibarri[SUP] 2 [/SUP], Julia Parise[SUP] 2 [/SUP], Amanda Arroyo[SUP] 2 [/SUP], Catherine Coriell[SUP] 2 [/SUP], Sydnee Goetz[SUP] 2 [/SUP], Carmen Moir[SUP] 2 [/SUP], Malini Govindan[SUP] 2 [/SUP], Atley Moberly[SUP] 2 [/SUP], Anna Proctor[SUP] 5 [/SUP], Katelyn Sainz[SUP] 6 [/SUP], Richard Blumrick[SUP] 7 [/SUP]
Affiliations
- PMID: 37454153
- PMCID: PMC10349851
- DOI: 10.1038/s41541-023-00698-8
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is associated with increased pregnancy complications. Despite effective vaccination strategies for the general population, the evidence on the safety and efficacy of Coronavirus disease 2019 (COVID-19) vaccinations in pregnancy is limited due to a lack of well-powered studies. The present study compares the maternal, neonatal, and immunological outcomes between vaccinated pregnant and unvaccinated pregnant women using a systematic review and meta-analysis approach. We included 37 studies with a total of 141,107 pregnant women (36.8% vaccinated) spread across all outcomes. Our evidence indicates a higher rate of cesarean section in the 1898 vaccinated pregnant women compared to the 6180 women who did not receive vaccination (OR = 1.20, CI = (1.05, 1.38), P = 0.007, I2 = 45%). Regarding immunological outcomes, the risk of SARS-CoV-2 infection during pregnancy or postpartum was significantly reduced in 6820 vaccinated pregnant women compared to 17,010 unvaccinated pregnant women (OR = 0.25, CI = 0.13-0.48, P < 0.0001, I[SUP]2[/SUP] = 61%), as evident from qualitative assessment indicating significantly higher postpartum antibody titers compared to that observed in both unvaccinated mothers and mothers who have recently recovered from a SARS-CoV-2 infection. Our analysis represents high quality evidence showing that COVID-19 vaccination effectively raises antibody titers against SARS-CoV-2. This may confer protection against infection during pregnancy and the postpartum period. In addition to being protective against SARS-CoV-2, the vaccine was associated with decreased odds of preterm delivery. Furthermore, COVID-19 vaccination may also be associated with higher odds of cesarean section.