tetano
Editor, Senior Moderator
NPJ Vaccines
. 2021 Feb 16;6(1):25.
doi: 10.1038/s41541-021-00289-5.
Immunogenicity of standard, high-dose, MF59-adjuvanted, and recombinant-HA seasonal influenza vaccination in older adults
Athena P Y Li[SUP] 1 [/SUP], Carolyn A Cohen[SUP] 1 [/SUP], Nancy H L Leung[SUP] 2 [/SUP], Vicky J Fang[SUP] 2 [/SUP], Shivaprakash Gangappa[SUP] 3 [/SUP], Suryaprakash Sambhara[SUP] 3 [/SUP], Min Z Levine[SUP] 3 [/SUP], A Danielle Iuliano[SUP] 3 [/SUP], Ranawaka A P M Perera[SUP] 2 [/SUP], Dennis K M Ip[SUP] 2 [/SUP], J S Malik Peiris[SUP] 1 2 [/SUP], Mark G Thompson[SUP] 3 [/SUP], Benjamin J Cowling[SUP] 2 [/SUP], Sophie A Valkenburg[SUP] 4 [/SUP]
Affiliations
Abstract
The vaccine efficacy of standard-dose seasonal inactivated influenza vaccines (S-IIV) can be improved by the use of vaccines with higher antigen content or adjuvants. We conducted a randomized controlled trial in older adults to compare cellular and antibody responses of S-IIV versus enhanced vaccines (eIIV): MF59-adjuvanted (A-eIIV), high-dose (H-eIIV), and recombinant-hemagglutinin (HA) (R-eIIV). All vaccines induced comparable H3-HA-specific IgG and elevated antibody-dependent cellular cytotoxicity (ADCC) activity at day 30 post vaccination. H3-HA-specific ADCC responses were greatest following H-eIIV. Only A-eIIV increased H3-HA-IgG avidity, HA-stalk IgG and ADCC activity. eIIVs also increased polyfunctional CD4+ and CD8+ T cell responses, while cellular immune responses were skewed toward single-cytokine-producing T cells among S-IIV subjects. Our study provides further immunological evidence for the preferential use of eIIVs in older adults as each vaccine platform had an advantage over the standard-dose vaccine in terms of NK cell activation, HA-stalk antibodies, and T cell responses.
. 2021 Feb 16;6(1):25.
doi: 10.1038/s41541-021-00289-5.
Immunogenicity of standard, high-dose, MF59-adjuvanted, and recombinant-HA seasonal influenza vaccination in older adults
Athena P Y Li[SUP] 1 [/SUP], Carolyn A Cohen[SUP] 1 [/SUP], Nancy H L Leung[SUP] 2 [/SUP], Vicky J Fang[SUP] 2 [/SUP], Shivaprakash Gangappa[SUP] 3 [/SUP], Suryaprakash Sambhara[SUP] 3 [/SUP], Min Z Levine[SUP] 3 [/SUP], A Danielle Iuliano[SUP] 3 [/SUP], Ranawaka A P M Perera[SUP] 2 [/SUP], Dennis K M Ip[SUP] 2 [/SUP], J S Malik Peiris[SUP] 1 2 [/SUP], Mark G Thompson[SUP] 3 [/SUP], Benjamin J Cowling[SUP] 2 [/SUP], Sophie A Valkenburg[SUP] 4 [/SUP]
Affiliations
- PMID: 33594050
- DOI: 10.1038/s41541-021-00289-5
Abstract
The vaccine efficacy of standard-dose seasonal inactivated influenza vaccines (S-IIV) can be improved by the use of vaccines with higher antigen content or adjuvants. We conducted a randomized controlled trial in older adults to compare cellular and antibody responses of S-IIV versus enhanced vaccines (eIIV): MF59-adjuvanted (A-eIIV), high-dose (H-eIIV), and recombinant-hemagglutinin (HA) (R-eIIV). All vaccines induced comparable H3-HA-specific IgG and elevated antibody-dependent cellular cytotoxicity (ADCC) activity at day 30 post vaccination. H3-HA-specific ADCC responses were greatest following H-eIIV. Only A-eIIV increased H3-HA-IgG avidity, HA-stalk IgG and ADCC activity. eIIVs also increased polyfunctional CD4+ and CD8+ T cell responses, while cellular immune responses were skewed toward single-cytokine-producing T cells among S-IIV subjects. Our study provides further immunological evidence for the preferential use of eIIVs in older adults as each vaccine platform had an advantage over the standard-dose vaccine in terms of NK cell activation, HA-stalk antibodies, and T cell responses.