tetano
Editor, Senior Moderator
Chem Commun (Camb). 2018 Jun 19. doi: 10.1039/c8cc03865a. [Epub ahead of print]
[h=1]Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection.[/h] Kosono S[SUP]1[/SUP], Kasai A[SUP]1[/SUP], Komaba S[SUP]1[/SUP], Matsubara T[SUP]2[/SUP], Sato T[SUP]2[/SUP], Takahashi D[SUP]1[/SUP], Toshima K[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C3-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.
PMID: 29915822 DOI: 10.1039/c8cc03865a
[h=1]Novel hemagglutinin-binding sulfated oligofucosides and their effect on influenza virus infection.[/h] Kosono S[SUP]1[/SUP], Kasai A[SUP]1[/SUP], Komaba S[SUP]1[/SUP], Matsubara T[SUP]2[/SUP], Sato T[SUP]2[/SUP], Takahashi D[SUP]1[/SUP], Toshima K[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Among a series of chemically synthesized fucoidan derivatives (1-9), 5 was found for the first time to bind to influenza virus hemagglutinins (HAs) and inhibit hemagglutination activity. In addition, a designed C3-symmetric tripodal ligand 10, synthesized with three sulfated oligofucoside moieties of 5, exhibited much greater hemagglutination inhibition activity than 5. A plaque assay using MDCK cells demonstrated that 10 effectively inhibited influenza virus infection.
PMID: 29915822 DOI: 10.1039/c8cc03865a