tetano
Editor, Senior Moderator
Transbound Emerg Dis. 2019 Oct 3. doi: 10.1111/tbed.13380. [Epub ahead of print] [h=1]Novel H5N6 Avian Influenza Virus Reassortants with European H5N8 Isolated in Migratory Birds, China.[/h]
Sun J[SUP]1[/SUP], Zhao L[SUP]2[/SUP], Li X[SUP]1[/SUP], Meng W[SUP]3[/SUP], Chu D[SUP]4[/SUP], Yang X[SUP]1[/SUP], Peng P[SUP]4[/SUP], Zhi M[SUP]1[/SUP], Qin S[SUP]4[/SUP], Fu T[SUP]1[/SUP], Li J[SUP]4[/SUP], Lu S[SUP]1[/SUP], Wang W[SUP]5[/SUP], He X[SUP]5[/SUP], Yu M[SUP]5[/SUP], Lv X[SUP]1[/SUP], Ma W[SUP]1[/SUP], Liao M[SUP]1[/SUP], Liu Z[SUP]1,[/SUP][SUP]6[/SUP], Zhang G[SUP]3[/SUP], Wang Y[SUP]1[/SUP], Li Y[SUP]2[/SUP], Chai H[SUP]1,[/SUP][SUP]6[/SUP], Lu J[SUP]3[/SUP], Hua Y[SUP]1[/SUP].
[h=3]Author information[/h] 1 College of Wildlife and Protected Area, Northeast Forestry University, Harbin150040, Heilongjiang Province, China. 2 State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin150040, Heilongjiang Province, China. 3 Research Institute of Forest Ecology, Environment and Protection, Chinese Academy of Forestry, Beijing, 100091, China. 4 General Station for Surveillance of Wildlife Disease & Wildlife Borne Diseases, National Forestry and Grassland Administration, Shenyang, 110000, Liaoning Province, China. 5 Monitoring Center for Terrestrial Wildlife Epidemic Diseases, Ningxia Hui Autonomous Region, Ningxia, Yinchuan, 750001, China. 6 Key Laboratory of Conservation Biology, National Forestry and Grassland Administration, Harbin, 150040, Heilongjiang Province, China.
[h=3]Abstract[/h] Five novel H5N6 influenza viruses, including four highly pathogenic avian influenza viruses and one low pathogenic avian influenza virus, were isolated from migratory birds in Ningxia, China in November 2017. To understand the genetic origination of the novel H5N6 virus, and the infectivity and pathogenicity of the four highly pathogenic avian influenza viruses in mammals, phylogeographic analyses and infection studies in mice were performed. The phylogenetic and phylogeographic analyses showed that the H5N6 isolates, which are closely related to the viruses from Korea, Japan and the Netherlands, originated from ressortant virus between H5N8 and HxN6 viruses from Western Russia. The animal study revealed that the SBD-87 isolate presented moderate virulence in mice, suggesting a potential public risk to humans and a potential threat to public health.
? 2019 Blackwell Verlag GmbH.
[h=4]KEYWORDS:[/h] Avian influenza virus; H5N6; Migratory birds; Pathogenicity; Phylogenetic
PMID: 31580519 DOI: 10.1111/tbed.13380
Sun J[SUP]1[/SUP], Zhao L[SUP]2[/SUP], Li X[SUP]1[/SUP], Meng W[SUP]3[/SUP], Chu D[SUP]4[/SUP], Yang X[SUP]1[/SUP], Peng P[SUP]4[/SUP], Zhi M[SUP]1[/SUP], Qin S[SUP]4[/SUP], Fu T[SUP]1[/SUP], Li J[SUP]4[/SUP], Lu S[SUP]1[/SUP], Wang W[SUP]5[/SUP], He X[SUP]5[/SUP], Yu M[SUP]5[/SUP], Lv X[SUP]1[/SUP], Ma W[SUP]1[/SUP], Liao M[SUP]1[/SUP], Liu Z[SUP]1,[/SUP][SUP]6[/SUP], Zhang G[SUP]3[/SUP], Wang Y[SUP]1[/SUP], Li Y[SUP]2[/SUP], Chai H[SUP]1,[/SUP][SUP]6[/SUP], Lu J[SUP]3[/SUP], Hua Y[SUP]1[/SUP].
[h=3]Author information[/h] 1 College of Wildlife and Protected Area, Northeast Forestry University, Harbin150040, Heilongjiang Province, China. 2 State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Harbin150040, Heilongjiang Province, China. 3 Research Institute of Forest Ecology, Environment and Protection, Chinese Academy of Forestry, Beijing, 100091, China. 4 General Station for Surveillance of Wildlife Disease & Wildlife Borne Diseases, National Forestry and Grassland Administration, Shenyang, 110000, Liaoning Province, China. 5 Monitoring Center for Terrestrial Wildlife Epidemic Diseases, Ningxia Hui Autonomous Region, Ningxia, Yinchuan, 750001, China. 6 Key Laboratory of Conservation Biology, National Forestry and Grassland Administration, Harbin, 150040, Heilongjiang Province, China.
[h=3]Abstract[/h] Five novel H5N6 influenza viruses, including four highly pathogenic avian influenza viruses and one low pathogenic avian influenza virus, were isolated from migratory birds in Ningxia, China in November 2017. To understand the genetic origination of the novel H5N6 virus, and the infectivity and pathogenicity of the four highly pathogenic avian influenza viruses in mammals, phylogeographic analyses and infection studies in mice were performed. The phylogenetic and phylogeographic analyses showed that the H5N6 isolates, which are closely related to the viruses from Korea, Japan and the Netherlands, originated from ressortant virus between H5N8 and HxN6 viruses from Western Russia. The animal study revealed that the SBD-87 isolate presented moderate virulence in mice, suggesting a potential public risk to humans and a potential threat to public health.
? 2019 Blackwell Verlag GmbH.
[h=4]KEYWORDS:[/h] Avian influenza virus; H5N6; Migratory birds; Pathogenicity; Phylogenetic
PMID: 31580519 DOI: 10.1111/tbed.13380