tetano
Editor, Senior Moderator
Vet Res. 2014 Dec 17;45(1):127.
[h=1]Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat.[/h] Li Q, Wang X, Gu M, Zhu J, Hao X, Gao Z, Sun Z, Hu J, Hu S, Wang X, Liu X, Liu X[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The emerging H5 clade 2.3.4.6 viruses of different NA subtypes have been detected in different domestic poultry in China. We evaluated the receptor binding property and transmissibility of four novel H5 clade 2.3.4.6 subtype highly pathogenic avian influenza viruses. The results show that these viruses bound to both avian-type (α-2,3) and human-type (α-2,6) receptors. Furthermore, we found that one of these viruses, GS/EC/1112/11, not only replicated but also transmitted efficiently in guinea pigs. Therefore, such novel H5 subtype viruses have the potential of a pandemic threat.
PMID: 25516306 [PubMed - as supplied by publisher] PMCID: PMC4268885 Free PMC Article
http://www.ncbi.nlm.nih.gov/pubmed/25516306
[h=1]Novel H5 clade 2.3.4.6 viruses with both α-2,3 and α-2,6 receptor binding properties may pose a pandemic threat.[/h] Li Q, Wang X, Gu M, Zhu J, Hao X, Gao Z, Sun Z, Hu J, Hu S, Wang X, Liu X, Liu X[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The emerging H5 clade 2.3.4.6 viruses of different NA subtypes have been detected in different domestic poultry in China. We evaluated the receptor binding property and transmissibility of four novel H5 clade 2.3.4.6 subtype highly pathogenic avian influenza viruses. The results show that these viruses bound to both avian-type (α-2,3) and human-type (α-2,6) receptors. Furthermore, we found that one of these viruses, GS/EC/1112/11, not only replicated but also transmitted efficiently in guinea pigs. Therefore, such novel H5 subtype viruses have the potential of a pandemic threat.
PMID: 25516306 [PubMed - as supplied by publisher] PMCID: PMC4268885 Free PMC Article
http://www.ncbi.nlm.nih.gov/pubmed/25516306