tetano
Editor, Senior Moderator
Sci Rep. 2016 Nov 16;6:37341. doi: 10.1038/srep37341.
[h=1]Non-neutralizing antibodies induced by seasonal influenza vaccine prevent, not exacerbate A(H1N1)pdm09 disease.[/h] Kim JH[SUP]1[/SUP], Reber AJ[SUP]1[/SUP], Kumar A[SUP]1[/SUP], Ramos P[SUP]1[/SUP], Sica G[SUP]2[/SUP], Music N[SUP]1[/SUP], Guo Z[SUP]1[/SUP], Mishina M[SUP]1,[/SUP][SUP]3[/SUP], Stevens J[SUP]1[/SUP], York IA[SUP]1[/SUP], Jacob J[SUP]4[/SUP], Sambhara S[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The association of seasonal trivalent influenza vaccine (TIV) with increased infection by 2009 pandemic H1N1 (A(H1N1)pdm09) virus, initially observed in Canada, has elicited numerous investigations on the possibility of vaccine-associated enhanced disease, but the potential mechanisms remain largely unresolved. Here, we investigated if prior immunization with TIV enhanced disease upon A(H1N1)pdm09 infection in mice. We found that A(H1N1)pdm09 infection in TIV-immunized mice did not enhance the disease, as measured by morbidity and mortality. Instead, TIV-immunized mice cleared A(H1N1)pdm09 virus and recovered at an accelerated rate compared to control mice. Prior TIV immunization was associated with potent inflammatory mediators and virus-specific CD8 T cell activation, but efficient immune regulation, partially mediated by IL-10R-signaling, prevented enhanced disease. Furthermore, in contrast to suggested pathological roles, pre-existing non-neutralizing antibodies (NNAbs) were not associated with enhanced virus replication, but rather with promoted antigen presentation through FcR-bearing cells that led to potent activation of virus-specific CD8 T cells. These findings provide new insights into interactions between pre-existing immunity and pandemic viruses.
PMID: 27849030 DOI: 10.1038/srep37341
[PubMed - in process] Free full text
[h=1]Non-neutralizing antibodies induced by seasonal influenza vaccine prevent, not exacerbate A(H1N1)pdm09 disease.[/h] Kim JH[SUP]1[/SUP], Reber AJ[SUP]1[/SUP], Kumar A[SUP]1[/SUP], Ramos P[SUP]1[/SUP], Sica G[SUP]2[/SUP], Music N[SUP]1[/SUP], Guo Z[SUP]1[/SUP], Mishina M[SUP]1,[/SUP][SUP]3[/SUP], Stevens J[SUP]1[/SUP], York IA[SUP]1[/SUP], Jacob J[SUP]4[/SUP], Sambhara S[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] The association of seasonal trivalent influenza vaccine (TIV) with increased infection by 2009 pandemic H1N1 (A(H1N1)pdm09) virus, initially observed in Canada, has elicited numerous investigations on the possibility of vaccine-associated enhanced disease, but the potential mechanisms remain largely unresolved. Here, we investigated if prior immunization with TIV enhanced disease upon A(H1N1)pdm09 infection in mice. We found that A(H1N1)pdm09 infection in TIV-immunized mice did not enhance the disease, as measured by morbidity and mortality. Instead, TIV-immunized mice cleared A(H1N1)pdm09 virus and recovered at an accelerated rate compared to control mice. Prior TIV immunization was associated with potent inflammatory mediators and virus-specific CD8 T cell activation, but efficient immune regulation, partially mediated by IL-10R-signaling, prevented enhanced disease. Furthermore, in contrast to suggested pathological roles, pre-existing non-neutralizing antibodies (NNAbs) were not associated with enhanced virus replication, but rather with promoted antigen presentation through FcR-bearing cells that led to potent activation of virus-specific CD8 T cells. These findings provide new insights into interactions between pre-existing immunity and pandemic viruses.
PMID: 27849030 DOI: 10.1038/srep37341
[PubMed - in process] Free full text