Missouriwatcher
Editor, Senior Moderator
16Mar 2011: FDA approval letter for Teva Women’s Health, Inc. to manufacture and sell Adenovirus Type 4 and Type 7 Vaccine, Live, Oral:
...Under this license, you are authorized to manufacture the product Adenovirus Type 4 and Type 7 Vaccine, Live, Oral, indicated for active immunization for the prevention of febrile acute respiratory disease caused by Adenovirus Type 4 and Type 7. Adenovirus Type 4 and Type 7 Vaccine, Live, Oral, is approved for use in military populations 17 through 50 years of age...
http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm247511.htm
Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 16, No. 5, May 2010
Spread of Adenovirus to Geographically Dispersed Military Installations, May–October 2007
Jill S. Trei,1 Natalie M. Johns, Jason L. Garner, Lawrence B. Noel, Brian V. Ortman, Kari L. Ensz, Matthew C. Johns, Michel L. Bunning, and Joel C. Gaydos
In mid-May 2007, a respiratory disease outbreak associated
with adenovirus, serotype B14 (Ad14), was recognized
at a large military basic training facility in Texas.
The affected population was highly mobile; after the 6-week
basic training course, trainees immediately dispersed to advanced
training sites worldwide... Ad14 spread readily to
secondary sites after the initial outbreak. Military and civilian
planners must consider how best to control the spread of
infectious respiratory diseases in highly mobile populations
traveling between diverse geographic locations...
Following the loss of the Ad4 and Ad7 vaccines, the
spread of Ad4 from an Army basic training site to a secondary
training installation was associated with a large
Ad4 outbreak at a secondary site...
http://www.cdc.gov/EID/content/16/5/pdfs/769.pdf
Two Fatal Cases of Adenovirus-Related Illness in Previously Healthy Young Adults — Illinois, 2000
...Adenovirus serotypes 4 and 7 have caused outbreaks of self-limited febrile respiratory illness in young adults in basic military training....Since 1999, approximately 10%–12% of all recruits have become ill with adenovirus infection in basic training, similar to the prevaccine era. This report describes the first two deaths probably associated with adenovirus infection identified in military recruits since the vaccines became unavailable...
CASE 1: ...Autopsy findings included histologic changes in the brain and spinal cord consistent with viral encephalitis. Both lungs showed bronchiolitis obliterans and organizing pneumonia. Cultures, special stains, and electron microscopy of autopsy specimens did not identify specific pathogens...
CASE 2: ...An autopsy revealed diffuse hemorrhagic pneumonia and diffuse alveolar injury. Cultures and special stains of autopsy materials failed to identify specific pathogens...
http://www.cdc.gov/mmwr/PDF/wk/mm5026.pdf
...Under this license, you are authorized to manufacture the product Adenovirus Type 4 and Type 7 Vaccine, Live, Oral, indicated for active immunization for the prevention of febrile acute respiratory disease caused by Adenovirus Type 4 and Type 7. Adenovirus Type 4 and Type 7 Vaccine, Live, Oral, is approved for use in military populations 17 through 50 years of age...
http://www.fda.gov/BiologicsBloodVaccines/Vaccines/ApprovedProducts/ucm247511.htm
Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 16, No. 5, May 2010
Spread of Adenovirus to Geographically Dispersed Military Installations, May–October 2007
Jill S. Trei,1 Natalie M. Johns, Jason L. Garner, Lawrence B. Noel, Brian V. Ortman, Kari L. Ensz, Matthew C. Johns, Michel L. Bunning, and Joel C. Gaydos
In mid-May 2007, a respiratory disease outbreak associated
with adenovirus, serotype B14 (Ad14), was recognized
at a large military basic training facility in Texas.
The affected population was highly mobile; after the 6-week
basic training course, trainees immediately dispersed to advanced
training sites worldwide... Ad14 spread readily to
secondary sites after the initial outbreak. Military and civilian
planners must consider how best to control the spread of
infectious respiratory diseases in highly mobile populations
traveling between diverse geographic locations...
Following the loss of the Ad4 and Ad7 vaccines, the
spread of Ad4 from an Army basic training site to a secondary
training installation was associated with a large
Ad4 outbreak at a secondary site...
http://www.cdc.gov/EID/content/16/5/pdfs/769.pdf
Two Fatal Cases of Adenovirus-Related Illness in Previously Healthy Young Adults — Illinois, 2000
...Adenovirus serotypes 4 and 7 have caused outbreaks of self-limited febrile respiratory illness in young adults in basic military training....Since 1999, approximately 10%–12% of all recruits have become ill with adenovirus infection in basic training, similar to the prevaccine era. This report describes the first two deaths probably associated with adenovirus infection identified in military recruits since the vaccines became unavailable...
CASE 1: ...Autopsy findings included histologic changes in the brain and spinal cord consistent with viral encephalitis. Both lungs showed bronchiolitis obliterans and organizing pneumonia. Cultures, special stains, and electron microscopy of autopsy specimens did not identify specific pathogens...
CASE 2: ...An autopsy revealed diffuse hemorrhagic pneumonia and diffuse alveolar injury. Cultures and special stains of autopsy materials failed to identify specific pathogens...
http://www.cdc.gov/mmwr/PDF/wk/mm5026.pdf