Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses

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J Virol. 2015 Apr 29. pii: JVI.00031-15. [Epub ahead of print]
[h=1]Newcastle disease virus-vectored H7 and H5 live vaccines protect chickens from challenge with H7N9 or H5N1 avian influenza viruses.[/h] Liu Q[SUP]1[/SUP], Mena I[SUP]2[/SUP], Ma J[SUP]1[/SUP], Bawa B[SUP]1[/SUP], Krammer F[SUP]3[/SUP], Lyoo YS[SUP]1[/SUP], Lang Y[SUP]1[/SUP], Morozov I[SUP]1[/SUP], Mahardika GN[SUP]4[/SUP], Ma W[SUP]1[/SUP], Garc?a-Sastre A[SUP]5[/SUP], Richt JA[SUP]6[/SUP].
[h=3]Author information[/h]

[h=3]Abstract[/h] Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that NDV-vectored H7 and NDV-H5 vaccines are able to induce high HI titer antibodies and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus expressed H7 protein failed to protect chicken from H7N9 infection.
Copyright ? 2015, American Society for Microbiology. All Rights Reserved.


PMID: 25926639 [PubMed - as supplied by publisher]