tetano
Editor, Senior Moderator
Bioorg Med Chem Lett. 2010 Sep 17. [Epub ahead of print]
New stilbenoid with inhibitory activity on viral neuraminidases from Erythrina addisoniae.
Nguyen PH, Na M, Dao TT, Ndinteh DT, Mbafor JT, Park J, Cheong H, Oh WK.
BK21 Project Team, College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju 501-759, Republic of Korea.
Abstract
Influenza occurs with seasonal variations and reaches the peak prevalence in winter causing the death of many people worldwide. A few inhibitors of viral neuraminidase, including amantadine, rimantadine, zanamivir, and oseltamivir, have been used as influenza therapy. However, as drug-resistant influenza viruses are generated rapidly, there is a need to identify new agents for chemotherapy against influenza. Therefore, research on more effective drugs has been given high priority. During the course of an anti-influenza screening program on natural products, two new compounds (1 and 2) along with seven known flavonoid derivatives (3-9) were isolated as active principles from an EtOAc-soluble extract of the root bark of Erythrina addisoniae. The stilbenoid (2) and chalcone (3, 4, and 6) compounds of the isolates exhibited stronger activity than the isoflavone ones. Compound 2, which is a formylated stilbenoid derivative, exhibited strong inhibition of both influenza H1N1 and H9N2 neuraminidases with IC(50) values of 8.80?0.34μg/mL and 7.19?0.40μg/mL, respectively.
PMID: 20934335 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20934335
New stilbenoid with inhibitory activity on viral neuraminidases from Erythrina addisoniae.
Nguyen PH, Na M, Dao TT, Ndinteh DT, Mbafor JT, Park J, Cheong H, Oh WK.
BK21 Project Team, College of Pharmacy, Chosun University, 375 Seosuk-dong, Dong-gu, Gwangju 501-759, Republic of Korea.
Abstract
Influenza occurs with seasonal variations and reaches the peak prevalence in winter causing the death of many people worldwide. A few inhibitors of viral neuraminidase, including amantadine, rimantadine, zanamivir, and oseltamivir, have been used as influenza therapy. However, as drug-resistant influenza viruses are generated rapidly, there is a need to identify new agents for chemotherapy against influenza. Therefore, research on more effective drugs has been given high priority. During the course of an anti-influenza screening program on natural products, two new compounds (1 and 2) along with seven known flavonoid derivatives (3-9) were isolated as active principles from an EtOAc-soluble extract of the root bark of Erythrina addisoniae. The stilbenoid (2) and chalcone (3, 4, and 6) compounds of the isolates exhibited stronger activity than the isoflavone ones. Compound 2, which is a formylated stilbenoid derivative, exhibited strong inhibition of both influenza H1N1 and H9N2 neuraminidases with IC(50) values of 8.80?0.34μg/mL and 7.19?0.40μg/mL, respectively.
PMID: 20934335 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20934335