tetano
Editor, Senior Moderator
New Microbes New Infect
. 2023 Mar;52:101096.
doi: 10.1016/j.nmni.2023.101096. Epub 2023 Feb 3.
SARS-COV-2 IgG specific antibodies persistence in recovered COVID-19 individuals and its association with severity and time of illness
Abdol Sattar Pagheh[SUP] 1 [/SUP], Arash Ziaee[SUP] 2 [/SUP], Khadijeh Abrari Romenjan[SUP] 1 [/SUP], Fatemeh Rezaei[SUP] 3 [/SUP], Babak Bahman[SUP] 1 [/SUP], Effat Alamzadeh[SUP] 1 [/SUP], Samira Elhamirad[SUP] 1 [/SUP], Masood Ziaee[SUP] 1 [/SUP]
Affiliations
Abstract
In order to accurately interpret the immune response to COVID-19, it is critical to know how long serum antibodies to COVID-2 persist. This study aimed to describe the serum IgG responses to SARS-CoV-2 in patients with mild, moderate, and severe COVID-19 infection in Birjand, South Khorasan province, Iran. The study was performed on individuals whose COVID-19 disease was confirmed by RT-PCR and recovered from the disease. After completing the questionnaire, blood samples were collected from 4 different groups based on the time of the test at two, four, six, and eight months' post-recovery. Then, SARS-COV-2 virus-specific IgG nucleocapsid antibody level in patients was measured using the enzyme-linked immunosorbent assay (ELISA). In total, 206 patients (mean age 44.19 ± 14.9, 51% man) were included in the survey. Serum prevalence of specific IgG antibodies in patients with mild, moderate, and severe COVID-19 disease was 51.5%, 64% and 78.9%, respectively. Furthermore, serum prevalence of COVID-19 specific IgG antibody level in two, four, six, and eight months after recovery were 80.8, 69.1, 43.2 and 41.8%, respectively (p < 0.05). The multiple logistic regression model showed that the variables of age and the time elapsed after recovery had a significant relationship with the positive antibody test of recovered COVID-19 patients (P < 0.05). But other variables had no significant relationship with the result of antibody test (P > 0.05). In the present report, we attempted to characterize the antibody response against SARS-CoV-2 in patients with mild, moderate, and severe COVID-19, with the aim of better elucidating the humoral immune response after recovery from SARS-CoV-2 infection.
Keywords: COVID-19; Coronavirus nucleocapsid protein; IgG; SARS-CoV-2; Severity.
. 2023 Mar;52:101096.
doi: 10.1016/j.nmni.2023.101096. Epub 2023 Feb 3.
SARS-COV-2 IgG specific antibodies persistence in recovered COVID-19 individuals and its association with severity and time of illness
Abdol Sattar Pagheh[SUP] 1 [/SUP], Arash Ziaee[SUP] 2 [/SUP], Khadijeh Abrari Romenjan[SUP] 1 [/SUP], Fatemeh Rezaei[SUP] 3 [/SUP], Babak Bahman[SUP] 1 [/SUP], Effat Alamzadeh[SUP] 1 [/SUP], Samira Elhamirad[SUP] 1 [/SUP], Masood Ziaee[SUP] 1 [/SUP]
Affiliations
- PMID: 36776158
- PMCID: PMC9896850
- DOI: 10.1016/j.nmni.2023.101096
Abstract
In order to accurately interpret the immune response to COVID-19, it is critical to know how long serum antibodies to COVID-2 persist. This study aimed to describe the serum IgG responses to SARS-CoV-2 in patients with mild, moderate, and severe COVID-19 infection in Birjand, South Khorasan province, Iran. The study was performed on individuals whose COVID-19 disease was confirmed by RT-PCR and recovered from the disease. After completing the questionnaire, blood samples were collected from 4 different groups based on the time of the test at two, four, six, and eight months' post-recovery. Then, SARS-COV-2 virus-specific IgG nucleocapsid antibody level in patients was measured using the enzyme-linked immunosorbent assay (ELISA). In total, 206 patients (mean age 44.19 ± 14.9, 51% man) were included in the survey. Serum prevalence of specific IgG antibodies in patients with mild, moderate, and severe COVID-19 disease was 51.5%, 64% and 78.9%, respectively. Furthermore, serum prevalence of COVID-19 specific IgG antibody level in two, four, six, and eight months after recovery were 80.8, 69.1, 43.2 and 41.8%, respectively (p < 0.05). The multiple logistic regression model showed that the variables of age and the time elapsed after recovery had a significant relationship with the positive antibody test of recovered COVID-19 patients (P < 0.05). But other variables had no significant relationship with the result of antibody test (P > 0.05). In the present report, we attempted to characterize the antibody response against SARS-CoV-2 in patients with mild, moderate, and severe COVID-19, with the aim of better elucidating the humoral immune response after recovery from SARS-CoV-2 infection.
Keywords: COVID-19; Coronavirus nucleocapsid protein; IgG; SARS-CoV-2; Severity.