http://www.nejm.org/doi/full/10.1056/NEJMoa1411680#t=articleTop
[...]
Here, we present the available data on the first 106 patients in whom EVD was diagnosed as the disease spread to Sierra Leone in order to provide a basis for understanding the clinical illness.
[...]
These relationships allowed us to observe incubation periods of 6 to 12 days, which is similar to that observed in the outbreak overall.
[...]
Patients who were younger than 21 years of age had a significantly lower case fatality rate than did patients older than 45 years of age (57% vs. 94%, P=0.03[...])
[...]
Patients between the ages of 21 and 45 years had an intermediate case fatality rate of 74%. There was no significant difference in the case fatality rate between males and females (73% and 75%, respectively).
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A positive correlation was noted between the viral load and the risk of death. Patients who presented with fewer than 100,000 EBOV copies per milliliter of serum had a case fatality rate of 33%, whereas those with a viral load of 10 million EBOV copies per milliliter or more had a significantly higher case fatality rate of 94% (P=0.003)
[...]
Although biased by the case definition, common findings included fever (in 89% of the patients), headache (in 80%), weakness (in 66%), dizziness (in 60%), diarrhea (in 51%), abdominal pain (in 40%), sore throat (in 34%), vomiting (in 34%), and conjunctivitis (in 31%)
[...]Among patients with diarrhea, 94% died, whereas only 65% of those without diarrhea on presentation died. Evidence of bleeding was noted in only 1 patient. None of the other 43 patients were reported to have hemorrhagic signs during their hospital stays, but the possibility cannot be definitively excluded because of the limited charting.
[...]
A documented fever (temperature, >38?C [100.4?F]), weakness, dizziness, and diarrhea on presentation were also associated with a fatal outcome. A number of dysfunctional hematologic and blood-system features have been described in experimental animals infected with EBOV.
[...]
Only 1 of 106 patients in our study cohort had overt bleeding at presentation. Although bleeding has been noted in previous outbreaks, our results show that this symptom is rare in the current outbreak.
[...]
[...]
Here, we present the available data on the first 106 patients in whom EVD was diagnosed as the disease spread to Sierra Leone in order to provide a basis for understanding the clinical illness.
[...]
These relationships allowed us to observe incubation periods of 6 to 12 days, which is similar to that observed in the outbreak overall.
[...]
Patients who were younger than 21 years of age had a significantly lower case fatality rate than did patients older than 45 years of age (57% vs. 94%, P=0.03[...])
[...]
Patients between the ages of 21 and 45 years had an intermediate case fatality rate of 74%. There was no significant difference in the case fatality rate between males and females (73% and 75%, respectively).
[...]
A positive correlation was noted between the viral load and the risk of death. Patients who presented with fewer than 100,000 EBOV copies per milliliter of serum had a case fatality rate of 33%, whereas those with a viral load of 10 million EBOV copies per milliliter or more had a significantly higher case fatality rate of 94% (P=0.003)
[...]
Although biased by the case definition, common findings included fever (in 89% of the patients), headache (in 80%), weakness (in 66%), dizziness (in 60%), diarrhea (in 51%), abdominal pain (in 40%), sore throat (in 34%), vomiting (in 34%), and conjunctivitis (in 31%)
[...]Among patients with diarrhea, 94% died, whereas only 65% of those without diarrhea on presentation died. Evidence of bleeding was noted in only 1 patient. None of the other 43 patients were reported to have hemorrhagic signs during their hospital stays, but the possibility cannot be definitively excluded because of the limited charting.
[...]
A documented fever (temperature, >38?C [100.4?F]), weakness, dizziness, and diarrhea on presentation were also associated with a fatal outcome. A number of dysfunctional hematologic and blood-system features have been described in experimental animals infected with EBOV.
[...]
Only 1 of 106 patients in our study cohort had overt bleeding at presentation. Although bleeding has been noted in previous outbreaks, our results show that this symptom is rare in the current outbreak.
[...]
