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http://feeds.univision.com/feeds/article/2012-04-24/nuevo-descubrimiento-sobre-el-origen
Spanish-English translation
New discovery about the origin of Leukemia can change therapy
EFE | Date: 04/24/2012
Vienna, April 24 (EFE). - The different varieties of leukemia B-ALL and CML are formed from a common predecessor cell, according to a team of scientists from the University of Veterinary Medicine Vienna, who say the finding will be " important consequences "for the treatment of disease.
In a statement released today, the university said the conclusions reached by the experts of the Faculty of Genetics and Animal Breeding, and Toxicology and Pharmacology, led by Boris Kovacic.
For scientists, the finding, the results have been published in the journal "EMBO Molecular Medicine", has been completely unexpected.
Questions the basis of current hypotheses on the formation of leukemia and "extremely important implications for the treatment of a particularly aggressive form" of this evil.
The note points out that many cancers are formed by mutations in body cells. So far it was assumed that the state of differentiation of these cells determines which specific type of cancer develops.
Thus, for example, the call chronic myeloid leukemia (CML) cells develop from bone marrow stem, while the B lymphocyte precursor cells would be at the origin of the cell acute lymphoblastic leukemia (B-ALL) .
But Kovacic team claims to have demonstrated that both varieties of the disease develop from hematopoietic stem cells.
It is in a later stage of development of cancer cells when both forms are different, and the most common cause of CML and B-ALL are two slightly divergent forms of BCR / ABL, appeared by mutation, and are known as "p210" and "p185".
According to Kovacic, the discovery shows that a therapy that attacks cancer cells all one way "can not work."
"We discover much more about the development of the disease. In the future we need a therapy directed at the real origins of both forms of leukemia: hematopoietic stem cells," added the expert in the note
Spanish-English translation
New discovery about the origin of Leukemia can change therapy
EFE | Date: 04/24/2012
Vienna, April 24 (EFE). - The different varieties of leukemia B-ALL and CML are formed from a common predecessor cell, according to a team of scientists from the University of Veterinary Medicine Vienna, who say the finding will be " important consequences "for the treatment of disease.
In a statement released today, the university said the conclusions reached by the experts of the Faculty of Genetics and Animal Breeding, and Toxicology and Pharmacology, led by Boris Kovacic.
For scientists, the finding, the results have been published in the journal "EMBO Molecular Medicine", has been completely unexpected.
Questions the basis of current hypotheses on the formation of leukemia and "extremely important implications for the treatment of a particularly aggressive form" of this evil.
The note points out that many cancers are formed by mutations in body cells. So far it was assumed that the state of differentiation of these cells determines which specific type of cancer develops.
Thus, for example, the call chronic myeloid leukemia (CML) cells develop from bone marrow stem, while the B lymphocyte precursor cells would be at the origin of the cell acute lymphoblastic leukemia (B-ALL) .
But Kovacic team claims to have demonstrated that both varieties of the disease develop from hematopoietic stem cells.
It is in a later stage of development of cancer cells when both forms are different, and the most common cause of CML and B-ALL are two slightly divergent forms of BCR / ABL, appeared by mutation, and are known as "p210" and "p185".
According to Kovacic, the discovery shows that a therapy that attacks cancer cells all one way "can not work."
"We discover much more about the development of the disease. In the future we need a therapy directed at the real origins of both forms of leukemia: hematopoietic stem cells," added the expert in the note