tetano
Editor, Senior Moderator
Scientists at the University of Illinois, Chicago, have identified a compound that effectively inhibits an enzyme crucial to the viruses that cause Middle East respiratory syndrome (MERS) and severe acute respiratory syndrome (SARS). The compound appears to have a different method of inhibition in each virus due to slight differences in each virus? enzyme which means finding other compounds that inhibit both may be difficult according to research presented at the 54th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) an infectious disease meeting of the American Society for Microbiology (ASM).
The enzyme, known as papain-like protease (PLpro) is considered essential to the coronavirus lifecycle and has been a promising target for years for drugs against SARS coronavirus (SARS-CoV). There are currently 2 groups of known SARS-CoV PLpro inhibitors. The researchers tested four compounds (2 each from 2 groups) for their ability to inhibit MERS-CoV PLpro.
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http://www.todaytopics.com/new-comp...-to-mers-and-sars-viruses-with-a-catch/28614/
The enzyme, known as papain-like protease (PLpro) is considered essential to the coronavirus lifecycle and has been a promising target for years for drugs against SARS coronavirus (SARS-CoV). There are currently 2 groups of known SARS-CoV PLpro inhibitors. The researchers tested four compounds (2 each from 2 groups) for their ability to inhibit MERS-CoV PLpro.
...
http://www.todaytopics.com/new-comp...-to-mers-and-sars-viruses-with-a-catch/28614/