• FluTrackers.com Inc. does not provide medical advice. Information on this web site is collected from various internet resources, and the FluTrackers board of directors makes no warranty to the safety, efficacy, correctness or completeness of the information posted on this site by any author or poster. The information collated here is for instructional and/or discussion purposes only and is NOT intended to diagnose or treat any disease, illness, or other medical condition. Every individual reader or poster should seek advice from their personal physician/healthcare practitioner before considering or using any interventions that are discussed on this website. By continuing to access this website you agree to consult your personal physican before using any interventions posted on this website, and you agree to hold harmless FluTrackers.com Inc., the board of directors, the members, and all authors and posters for any effects from use of any medication, supplement, vitamin or other substance, device, intervention, etc. mentioned in posts on this website, or other internet venues referenced in posts on this website.
  • We are not asking for any donations. Do not donate to any entity who says they are raising funds for us.

New and more aggressive HIV strain leads much sooner to Aids

Gert van der Hoek

In Memoriam - Editor, Senior Moderator
New HIV strain discovered in West Africa leads much sooner to Aids

Saturday, 30 November, 2013

A new and more aggressive strain of HIV discovered in West Africa causes significantly faster progression to Aids, researchers at Sweden's Lund University said.

The new strain of the virus that causes Aids, called A3/02, is a fusion of the two most common HIV strains in Guinea-Bissau. It has so far only been found in West Africa.

"Individuals who are infected with the new recombinant form develop Aids within five years, and that's about two to two-and-a-half years faster than one of the parent (strains)," said Angelica Palm, one of the scientists responsible for the study based on a long-term follow-up of HIV-positive people in Guinea-Bissau.

Read more: SCMP



Aggressive New HIV Strain In West Africa Develops Into AIDS More Rapidly: What Is A 'Recombinant' Virus?

By Susan Scutti | Nov 29, 2013

Over 60 epidemic strains of HIV-1 exist in the world, so when researchers discovered a new one in West Africa, the only alarm bell that sounded was the fact that this new strain progresses very rapidly. This new bug can progress from infection to the development of AIDS in just about five years. “Individuals infected with [the new strain] have among the fastest progression rates to AIDS reported to date,” wrote the authors in their study.

Recombinant Forms
The new strain is known as a recombinant form of the virus; geographic regions are often dominated by only one or two epidemic strains of HIV, and sometimes a person may become infected with two different strains, usually because they have traveled to or met someone from another region. In such cases, two strains of the virus may meld and form a “recombinant.” The recombinant discovered by the Swedish researchers, during long-term follow-up of HIV-infected individuals in Guinea-Bissau, is called A3/02 and is a cross between the most common strains, 02AG and A3, found in that region of West Africa. So far, the new strain has only been identified in West Africa.

Read more: Medical Daily
 
Re: New and more aggressive HIV strain leads much sooner to Aids

From ProMED:

...

Date: Fri 9 Aug 2013
Source: The publication referred to in the above press report is entitled: Faster Progression to AIDS and AIDS-Related Death Among Seroincident Individuals Infected with Recombinant HIV-1 A3/CRF02_AG Compared with Sub-subtype A3. By Angelica A. Palm and 9 others, in J Infect Dis. (2013):10.1093/infdis/jit416. [edited]


Abstract
--------
Background: Human immunodeficiency virus type 1 (HIV-1) is divided into subtypes and circulating recombinant forms (CRFs) but the impact of subtype/CRF on disease progression is not fully understood.

Methods: We determined the HIV-1 subtype/CRF of 152 seroincident individuals from Guinea-Bissau, based on the C2-V3 region of _env_. Disease progression was measured as time from estimated seroconversion to AIDS and AIDS-related death. Hazard ratios (HRs) were calculated using a Cox proportional hazard model, adjusting for gender and age at seroconversion.

Results: The major subtypes/CRFs identified were CRF02_AG (53 percent), A3 (29 percent), and A3/02 (a recombinant of A3 and CRF02_AG) (13 percent). Infection with A3/02 was associated with a close to 3-fold increased risk of AIDS and AIDS-related death compared to A3 (HR = 2.6 [P = 0.011] and 2.9 [P= 0.032], respectively). The estimated time from seroconversion to AIDS and AIDS-related death was 5.0 and 8.0 years for A3/02, 6.2 and 9.0 years for CRF02_AG, and 7.2 and 11.3 years for A3.

Conclusion: Our results show that there are differences in disease progression between HIV-1 A-like subtypes/CRFs. Individuals infected with A3/02 have among the fastest progression rates to AIDS reported to date. Determining the HIV-1 subtype of infected individuals could be important in the management of HIV-1 infections.

Communicated by:
ProMED-mail
<promed@promedmail.org>

[It remains to be seen whether this new recombinant, exhibiting enhanced disease progression, will remain confined to Guinea-Bissau or will spread beyond its present bounds. - Mod.CP

http://beta.promedmail.org/direct.php?id=20131130.2082684
 
Back
Top