tetano
Editor, Senior Moderator
Immunol Lett. 2014 Jan 21. pii: S0165-2478(14)00010-8. doi: 10.1016/j.imlet.2014.01.006. [Epub ahead of print]
New advances in mucosal vaccination.
Ranasinghe C.
Author information
Abstract
The ICI 2013 Mucosal Vaccine Workshop presentations covered a wide range of topics, these mainly fell into three categories; i) Understanding the interactions of host and microbes, specifically commensal pathogens and improving the antigen uptake via the (microfold cells) M cells to induce effective IgA antibody immunity at the gut mucosa; ii) Effective plant-based vaccines and iii) development of prophylactic and therapeutic mucosal-based vaccine strategies for virus infections such as Human immunodeficiency virus (HIV), influenza and Human Papillomavirus (HPV) associated head and neck cancers. How to improve the efficacy of oral vaccines, novel intranasal mucosal adjuvants and a unique intra-cheek delivery method were also discussed. Presenters emphasized the differences associated with systemic and mucosal vaccination, specifically, how mucosal vaccines unlike systemic delivery can induce effective immunity at the first line of defence. Collectively, the workshop provided insights into recent developments in the mucosal vaccine research field, highlighting the complexities associated with designing safe and effective mucosal vaccines.
Copyright ? 2014 The Author. Published by Elsevier B.V. All rights reserved.
KEYWORDS:
IgA, Intra-cheek delivery, Intranasal, M cells, Mucosal adjuvants, Mucosal vaccines, Oral, Plant-based vaccines, T cell avidity, autophagy
PMID:
24462961
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24462961
New advances in mucosal vaccination.
Ranasinghe C.
Author information
Abstract
The ICI 2013 Mucosal Vaccine Workshop presentations covered a wide range of topics, these mainly fell into three categories; i) Understanding the interactions of host and microbes, specifically commensal pathogens and improving the antigen uptake via the (microfold cells) M cells to induce effective IgA antibody immunity at the gut mucosa; ii) Effective plant-based vaccines and iii) development of prophylactic and therapeutic mucosal-based vaccine strategies for virus infections such as Human immunodeficiency virus (HIV), influenza and Human Papillomavirus (HPV) associated head and neck cancers. How to improve the efficacy of oral vaccines, novel intranasal mucosal adjuvants and a unique intra-cheek delivery method were also discussed. Presenters emphasized the differences associated with systemic and mucosal vaccination, specifically, how mucosal vaccines unlike systemic delivery can induce effective immunity at the first line of defence. Collectively, the workshop provided insights into recent developments in the mucosal vaccine research field, highlighting the complexities associated with designing safe and effective mucosal vaccines.
Copyright ? 2014 The Author. Published by Elsevier B.V. All rights reserved.
KEYWORDS:
IgA, Intra-cheek delivery, Intranasal, M cells, Mucosal adjuvants, Mucosal vaccines, Oral, Plant-based vaccines, T cell avidity, autophagy
PMID:
24462961
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24462961