tetano
Editor, Senior Moderator
Vopr Virusol. 2011 Mar-Apr;56(2):36-9.
[New adamantane derivatives and ways of overcoming the resistance of influenza A viruses to rimantadine and amantadine].
[Article in Russian]
[No authors listed]
Abstract
The amino acid and peptide derivatives of 1-adamantane carboxylic acid and rimantadine (18 compounds) have been first synthesized and investigated for their activity against influenza A virus (H1N1, H1N1v). In a series of obtained adamantine derivatives, some compounds have been found to be able to inhibit rimantadine-resistant influenza A virus strains. Thus, the antiviral properties of rimantadine can be restored.
PMID:
21545040
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/21545040
[New adamantane derivatives and ways of overcoming the resistance of influenza A viruses to rimantadine and amantadine].
[Article in Russian]
[No authors listed]
Abstract
The amino acid and peptide derivatives of 1-adamantane carboxylic acid and rimantadine (18 compounds) have been first synthesized and investigated for their activity against influenza A virus (H1N1, H1N1v). In a series of obtained adamantine derivatives, some compounds have been found to be able to inhibit rimantadine-resistant influenza A virus strains. Thus, the antiviral properties of rimantadine can be restored.
PMID:
21545040
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/21545040