tetano
Editor, Senior Moderator
Clin Vaccine Immunol. 2016 Aug 24. pii: CVI.00297-16. [Epub ahead of print]
[h=1]Neutralizing Antibody Responses to Antigenically Drifted Influenza A(H3N2) viruses Among Children and Adolescents Following 2014-15 Inactivated and Live Attenuated Influenza Vaccination.[/h] Levine MZ[SUP]1[/SUP], Martin JM[SUP]2[/SUP], Gross FL[SUP]3[/SUP], Jefferson S[SUP]4[/SUP], Cole KS[SUP]5[/SUP], Archibald C[SUP]6[/SUP], Nowalk MP[SUP]2[/SUP], Susick M[SUP]2[/SUP], Moehling K[SUP]2[/SUP], Spencer S[SUP]7[/SUP], Chung JR[SUP]7[/SUP], Flannery B[SUP]4[/SUP], Zimmerman RK[SUP]8[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Human influenza A(H3N2) viruses that predominated during the moderately severe 2014-15 influenza season differed antigenically from the vaccine component, resulting in reduced vaccine effectiveness (VE). To examine antibody responses to 2014-2015 inactivated influenza vaccine (IIV) and live-attenuated influenza vaccine (LAIV) among children and adolescents, we collected sera before and after vaccination from 150 children aged 3-17 years enrolled at health care facilities. Hemagglutination inhibition assays (HI) were used to assess the antibody responses to vaccines strains. We evaluated cross-reactive antibody responses against two representative A(H3N2) viruses that were antigenically drifted from the A(H3N2) vaccine component using microneutralization (MN) assays. Post vaccination antibody titers to drifted A(H3N2) viruses were higher following receipt of IIV (MN GMT 63-68, 38-45% achieved seroconversion) versus LAIV (MN GMT 22, only 3-5% achieved seroconversion). In 9-17 year olds, highest MN titers were observed among IIV-vaccinated individuals who received LAIV in the previous season. Among all IIV recipients aged 3-17 years, the strongest predictor of antibody responses to the drifted viruses was the pre-vaccination titers to the vaccine strain. Our study suggests that in an antigenically drifted season, vaccination still induced cross-reactive antibody responses to drifted circulating A(H3N2) viruses, although higher antibody titers may be required for protection. Antibody responses to drifted A(H3N2) viruses following vaccination were influenced by multiple factors including vaccine type and pre-existing antibodies from prior exposure.
Copyright ? 2016 Levine et al.
PMID: 27558294 DOI: 10.1128/CVI.00297-16
[PubMed - as supplied by publisher] Free full text
[h=1]Neutralizing Antibody Responses to Antigenically Drifted Influenza A(H3N2) viruses Among Children and Adolescents Following 2014-15 Inactivated and Live Attenuated Influenza Vaccination.[/h] Levine MZ[SUP]1[/SUP], Martin JM[SUP]2[/SUP], Gross FL[SUP]3[/SUP], Jefferson S[SUP]4[/SUP], Cole KS[SUP]5[/SUP], Archibald C[SUP]6[/SUP], Nowalk MP[SUP]2[/SUP], Susick M[SUP]2[/SUP], Moehling K[SUP]2[/SUP], Spencer S[SUP]7[/SUP], Chung JR[SUP]7[/SUP], Flannery B[SUP]4[/SUP], Zimmerman RK[SUP]8[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Human influenza A(H3N2) viruses that predominated during the moderately severe 2014-15 influenza season differed antigenically from the vaccine component, resulting in reduced vaccine effectiveness (VE). To examine antibody responses to 2014-2015 inactivated influenza vaccine (IIV) and live-attenuated influenza vaccine (LAIV) among children and adolescents, we collected sera before and after vaccination from 150 children aged 3-17 years enrolled at health care facilities. Hemagglutination inhibition assays (HI) were used to assess the antibody responses to vaccines strains. We evaluated cross-reactive antibody responses against two representative A(H3N2) viruses that were antigenically drifted from the A(H3N2) vaccine component using microneutralization (MN) assays. Post vaccination antibody titers to drifted A(H3N2) viruses were higher following receipt of IIV (MN GMT 63-68, 38-45% achieved seroconversion) versus LAIV (MN GMT 22, only 3-5% achieved seroconversion). In 9-17 year olds, highest MN titers were observed among IIV-vaccinated individuals who received LAIV in the previous season. Among all IIV recipients aged 3-17 years, the strongest predictor of antibody responses to the drifted viruses was the pre-vaccination titers to the vaccine strain. Our study suggests that in an antigenically drifted season, vaccination still induced cross-reactive antibody responses to drifted circulating A(H3N2) viruses, although higher antibody titers may be required for protection. Antibody responses to drifted A(H3N2) viruses following vaccination were influenced by multiple factors including vaccine type and pre-existing antibodies from prior exposure.
Copyright ? 2016 Levine et al.
PMID: 27558294 DOI: 10.1128/CVI.00297-16
[PubMed - as supplied by publisher] Free full text