tetano
Editor, Senior Moderator
Neurosci Lett
. 2020 Dec 19;135567.
doi: 10.1016/j.neulet.2020.135567. Online ahead of print.
Neurological Issues in Children with COVID-19
Jieru E Lin[SUP] 1 [/SUP], Arsenoi Asfour[SUP] 1 [/SUP], Taylor B Sewell[SUP] 2 [/SUP], Benjamin Hooe[SUP] 2 [/SUP], Patrice Pryce[SUP] 2 [/SUP], Chelsea Earley[SUP] 1 [/SUP], Min Ye Shen[SUP] 1 [/SUP], Mallory Kerner-Rossi[SUP] 1 [/SUP], Kiran T Thakur[SUP] 3 [/SUP], Wendy S Vargas[SUP] 4 [/SUP], Wendy G Silver[SUP] 4 [/SUP], Andrew S Geneslaw[SUP] 5 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious disease course in children, but serious complications may occur in conjunction with both acute infection and associated phenomena such as the multisystem inflammatory syndrome in children (MIS-C). Neurological symptoms, which have been predominantly reported in adults, range from mild headache to seizure, peripheral neuropathy, stroke, demyelinating disorders, and encephalopathy. Similar to respiratory and cardiac manifestations of COVID-19, neurological complications present differently based on age and underlying comorbidities. This review provides a concise overview of the neurological conditions seen in the context of COVID-19, as well as potential mechanisms and long-term implications of COVID-19 in the pediatric population from literature reviews and primary data collected at Morgan Stanley Children's Hospital in New York City.
Keywords: COVID-19; SARS-CoV-2; multisystem inflammatory syndrome in children (MIS-C); pediatrics.
. 2020 Dec 19;135567.
doi: 10.1016/j.neulet.2020.135567. Online ahead of print.
Neurological Issues in Children with COVID-19
Jieru E Lin[SUP] 1 [/SUP], Arsenoi Asfour[SUP] 1 [/SUP], Taylor B Sewell[SUP] 2 [/SUP], Benjamin Hooe[SUP] 2 [/SUP], Patrice Pryce[SUP] 2 [/SUP], Chelsea Earley[SUP] 1 [/SUP], Min Ye Shen[SUP] 1 [/SUP], Mallory Kerner-Rossi[SUP] 1 [/SUP], Kiran T Thakur[SUP] 3 [/SUP], Wendy S Vargas[SUP] 4 [/SUP], Wendy G Silver[SUP] 4 [/SUP], Andrew S Geneslaw[SUP] 5 [/SUP]
Affiliations
- PMID: 33352286
- DOI: 10.1016/j.neulet.2020.135567
Abstract
Coronavirus disease 2019 (COVID-19) usually leads to a mild infectious disease course in children, but serious complications may occur in conjunction with both acute infection and associated phenomena such as the multisystem inflammatory syndrome in children (MIS-C). Neurological symptoms, which have been predominantly reported in adults, range from mild headache to seizure, peripheral neuropathy, stroke, demyelinating disorders, and encephalopathy. Similar to respiratory and cardiac manifestations of COVID-19, neurological complications present differently based on age and underlying comorbidities. This review provides a concise overview of the neurological conditions seen in the context of COVID-19, as well as potential mechanisms and long-term implications of COVID-19 in the pediatric population from literature reviews and primary data collected at Morgan Stanley Children's Hospital in New York City.
Keywords: COVID-19; SARS-CoV-2; multisystem inflammatory syndrome in children (MIS-C); pediatrics.