tetano
Editor, Senior Moderator
Neurosci Biobehav Rev
. 2020 Oct 19;119:184-193.
doi: 10.1016/j.neubiorev.2020.10.012. Online ahead of print.
Neurotropism of SARS-CoV-2 and its neuropathological alterations: similarities with other coronaviruses
Jingman Hu[SUP] 1 [/SUP], Jukka Jolkkonen[SUP] 2 [/SUP], Chuansheng Zhao[SUP] 3 [/SUP]
Affiliations
Abstract
A novel coronavirus (SARS-CoV-2) emerged from Wuhan, China, and spread quickly around the world. In addition to fever, cough and shortness of breath, it was confirmed that the patients also have manifestations towards the central nervous system (CNS), especially those critically ill ones. In this review, we will discuss how SARS-CoV-2 gain access to the CNS and the possible consequences. Both SARS-CoV-2 and SARS-CoV-1 in 2002 share the same receptor angiotensin-converting enzyme 2 (ACE2), which can be found in the brain and mediate the disease process. Both direct attack of SARS-CoV-2 and the abnormal immune response in the CNS would contribute to the disease. Also, there is a relationship between SARS-CoV-2 and the occurrence of acute cerebrovascular diseases.
Keywords: COVID-19; coronavirus; nervous system; neuropathological alterations.
. 2020 Oct 19;119:184-193.
doi: 10.1016/j.neubiorev.2020.10.012. Online ahead of print.
Neurotropism of SARS-CoV-2 and its neuropathological alterations: similarities with other coronaviruses
Jingman Hu[SUP] 1 [/SUP], Jukka Jolkkonen[SUP] 2 [/SUP], Chuansheng Zhao[SUP] 3 [/SUP]
Affiliations
- PMID: 33091416
- PMCID: PMC7571477
- DOI: 10.1016/j.neubiorev.2020.10.012
Abstract
A novel coronavirus (SARS-CoV-2) emerged from Wuhan, China, and spread quickly around the world. In addition to fever, cough and shortness of breath, it was confirmed that the patients also have manifestations towards the central nervous system (CNS), especially those critically ill ones. In this review, we will discuss how SARS-CoV-2 gain access to the CNS and the possible consequences. Both SARS-CoV-2 and SARS-CoV-1 in 2002 share the same receptor angiotensin-converting enzyme 2 (ACE2), which can be found in the brain and mediate the disease process. Both direct attack of SARS-CoV-2 and the abnormal immune response in the CNS would contribute to the disease. Also, there is a relationship between SARS-CoV-2 and the occurrence of acute cerebrovascular diseases.
Keywords: COVID-19; coronavirus; nervous system; neuropathological alterations.