tetano
Editor, Senior Moderator
Neuropsychiatr Dis Treat
. 2024 Jun 20:20:1321-1330.
doi: 10.2147/NDT.S462496. eCollection 2024. Abnormal Serum Biochemical Results and Mitochondrial Damage of Lymphocytes in Patients with Schizophrenia and SARS-CoV-2 Infection: A Retrospective Study
Qiao Zhang[SUP] #[/SUP][SUP] 1 [/SUP], Lei Shi[SUP] #[/SUP][SUP] 1 [/SUP], Yanping Lin[SUP] #[/SUP][SUP] 2 [/SUP], Huirong Dai[SUP] 1 [/SUP], Yixuan Bai[SUP] 1 [/SUP], Pan You[SUP] 1 [/SUP]
Affiliations
Purpose: In this study, we investigated the differences in clinical biochemical values and mitochondrial mass between schizophrenia patients with and without COVID-19, so as to provide assistance to the treatment and management of COVID-19 positive patients with schizophrenia.
Patients and methods: We undertook an exploratory, retrospective review of patient data from Dec. 6, 2022, to Jan. 31, 2023. A total of 1696 inpatients with psychosis (921 schizophrenia patients and 775 diagnosed with other mental diseases) during this period were identified. Finally, 60 schizophrenia patients were enrolled in our study, and 20 of them were infected with syndrome coronavirus 2 (SARS-CoV-2). The serum biochemical levels and single-cell mitochondrial mass (SCMM) of the T lymphocytes of all schizophrenia patients were analyzed.
Results: The serum levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatinine (Cr) and lactate dehydrogenase (LDH) were significantly higher in schizophrenia patients with COVID-19 (SCZ-C) group. In addition, the SCZ-C group showed lower CD3[SUP]+[/SUP], CD3[SUP]+[/SUP]CD4[SUP]+[/SUP] and CD3[SUP]+[/SUP]CD8[SUP]+[/SUP] cell counts and higher SCMM of T lymphocytes compared to SCZ group. Furthermore, positive correlations were found between the T-cell subpopulation counts and positive symptom scores on the Positive and Negative Syndrome Scale (PANSS).
Conclusion: Our study findings showed that schizophrenia patients with COVID-19 have a phenotype of mitochondrial damage in T lymphocytes and higher serum levels of AST, ALP, Cr and LDH, which might provide evidence for treating individuals with schizophrenia during subsequent spread of infectious disease.
Keywords: COVID-19; biochemical characteristics; lymphocyte; mitochondrial damage; schizophrenia.
. 2024 Jun 20:20:1321-1330.
doi: 10.2147/NDT.S462496. eCollection 2024. Abnormal Serum Biochemical Results and Mitochondrial Damage of Lymphocytes in Patients with Schizophrenia and SARS-CoV-2 Infection: A Retrospective Study
Qiao Zhang[SUP] #[/SUP][SUP] 1 [/SUP], Lei Shi[SUP] #[/SUP][SUP] 1 [/SUP], Yanping Lin[SUP] #[/SUP][SUP] 2 [/SUP], Huirong Dai[SUP] 1 [/SUP], Yixuan Bai[SUP] 1 [/SUP], Pan You[SUP] 1 [/SUP]
Affiliations
- PMID: 38933096
- PMCID: PMC11199166
- DOI: 10.2147/NDT.S462496
Purpose: In this study, we investigated the differences in clinical biochemical values and mitochondrial mass between schizophrenia patients with and without COVID-19, so as to provide assistance to the treatment and management of COVID-19 positive patients with schizophrenia.
Patients and methods: We undertook an exploratory, retrospective review of patient data from Dec. 6, 2022, to Jan. 31, 2023. A total of 1696 inpatients with psychosis (921 schizophrenia patients and 775 diagnosed with other mental diseases) during this period were identified. Finally, 60 schizophrenia patients were enrolled in our study, and 20 of them were infected with syndrome coronavirus 2 (SARS-CoV-2). The serum biochemical levels and single-cell mitochondrial mass (SCMM) of the T lymphocytes of all schizophrenia patients were analyzed.
Results: The serum levels of aspartate aminotransferase (AST), alkaline phosphatase (ALP), creatinine (Cr) and lactate dehydrogenase (LDH) were significantly higher in schizophrenia patients with COVID-19 (SCZ-C) group. In addition, the SCZ-C group showed lower CD3[SUP]+[/SUP], CD3[SUP]+[/SUP]CD4[SUP]+[/SUP] and CD3[SUP]+[/SUP]CD8[SUP]+[/SUP] cell counts and higher SCMM of T lymphocytes compared to SCZ group. Furthermore, positive correlations were found between the T-cell subpopulation counts and positive symptom scores on the Positive and Negative Syndrome Scale (PANSS).
Conclusion: Our study findings showed that schizophrenia patients with COVID-19 have a phenotype of mitochondrial damage in T lymphocytes and higher serum levels of AST, ALP, Cr and LDH, which might provide evidence for treating individuals with schizophrenia during subsequent spread of infectious disease.
Keywords: COVID-19; biochemical characteristics; lymphocyte; mitochondrial damage; schizophrenia.