tetano
Editor, Senior Moderator
Neuropediatrics
. 2022 Dec 23.
doi: 10.1055/s-0042-1757710. Online ahead of print.
Supratentorial Demyelinating Lesions Following Severe Acute Respiratory Syndrome Coronavirus-2 Infection: A Pediatric Case Report
Silvia Boeri[SUP] 1 2 [/SUP], Marina Martinez Popple[SUP] 1 2 [/SUP], Thea Giacomini[SUP] 1 [/SUP], Tommaso Bellini[SUP] 3 [/SUP], Mariasavina Severino[SUP] 4 [/SUP], Andrea Rossi[SUP] 4 [/SUP], Carla Debbia[SUP] 3 [/SUP], Silvana Ancona[SUP] 2 [/SUP], Elena Aldera[SUP] 2 [/SUP], Lino Nobili[SUP] 1 2 [/SUP], Laura Siri[SUP] 1 [/SUP]
Affiliations
Abstract
Introduction: Most coronavirus disease 2019 (COVID-19) pediatric patients are asymptomatic; however, several neurological manifestations associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection have been reported. Demyelinating events such as acute disseminated encephalomyelitis have been recently included among potential complications of COVID-19.
Case report: We describe the case of a 12-year-old boy who developed central nervous system demyelinating lesions following SARS-CoV-2 infection. Two months prior he had been diagnosed with panuveitis but was otherwise healthy. Three weeks after testing positive for SARS-CoV-2, he started to complain of right temporal headache associated with right orbital pain without vision impairment. Brain magnetic resonance imaging showed large leukodystrophy-like demyelinating lesions. Standard electroencephalogram revealed a slow activity on the right hemisphere. His clinical and electroencephalographic course was favorable, with a good response to corticosteroid therapy and infusions of intravenous immunoglobulins. Delayed but complete resolution of brain lesions was noted on imaging.
Conclusions: Our case contributes to broaden the knowledge regarding the spectrum of possible complications of SARS-CoV-2 infection. The relative lack of clinical manifestations in our patient can be seen as a warning not to underestimate even mild neurological symptoms correlated with COVID-19.
. 2022 Dec 23.
doi: 10.1055/s-0042-1757710. Online ahead of print.
Supratentorial Demyelinating Lesions Following Severe Acute Respiratory Syndrome Coronavirus-2 Infection: A Pediatric Case Report
Silvia Boeri[SUP] 1 2 [/SUP], Marina Martinez Popple[SUP] 1 2 [/SUP], Thea Giacomini[SUP] 1 [/SUP], Tommaso Bellini[SUP] 3 [/SUP], Mariasavina Severino[SUP] 4 [/SUP], Andrea Rossi[SUP] 4 [/SUP], Carla Debbia[SUP] 3 [/SUP], Silvana Ancona[SUP] 2 [/SUP], Elena Aldera[SUP] 2 [/SUP], Lino Nobili[SUP] 1 2 [/SUP], Laura Siri[SUP] 1 [/SUP]
Affiliations
- PMID: 36564023
- DOI: 10.1055/s-0042-1757710
Abstract
Introduction: Most coronavirus disease 2019 (COVID-19) pediatric patients are asymptomatic; however, several neurological manifestations associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection have been reported. Demyelinating events such as acute disseminated encephalomyelitis have been recently included among potential complications of COVID-19.
Case report: We describe the case of a 12-year-old boy who developed central nervous system demyelinating lesions following SARS-CoV-2 infection. Two months prior he had been diagnosed with panuveitis but was otherwise healthy. Three weeks after testing positive for SARS-CoV-2, he started to complain of right temporal headache associated with right orbital pain without vision impairment. Brain magnetic resonance imaging showed large leukodystrophy-like demyelinating lesions. Standard electroencephalogram revealed a slow activity on the right hemisphere. His clinical and electroencephalographic course was favorable, with a good response to corticosteroid therapy and infusions of intravenous immunoglobulins. Delayed but complete resolution of brain lesions was noted on imaging.
Conclusions: Our case contributes to broaden the knowledge regarding the spectrum of possible complications of SARS-CoV-2 infection. The relative lack of clinical manifestations in our patient can be seen as a warning not to underestimate even mild neurological symptoms correlated with COVID-19.